Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population

Jeffrey C. Long*, William C. Knowler, Robert L. Hanson, Robert W. Robin, Margrit Urbanek, Elisa Moore, Peter H. Bennett, David Goldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

334 Scopus citations

Abstract

To identify specific genes affecting vulnerability or resistance, we performed a whole-autosomal genome scan for genetic linkage to alcohol dependence in a Southwestern American Indian tribe. Genotypes at 517 autosomal microsatellite loci and clinical evaluations were available for 152 subjects belonging to extended pedigrees and forming 172 sib-pairs. Highly suggestive evidence for linkage emerged for two genomic regions using two- and multipoint sib-pair regression methods; both regions harbored neurogenetic candidate genes. The best evidence is seen with D11S1984 (nominal P = 0.00007, lod ≃ 3.1) on chromosome 11p, in close proximity to the DRD4 dopamine receptor and tyrosine hydroxylase (TH) genes. Good evidence is seen with D4S3242 (nominal P = 0.0002, lod ≃ 2.8) on chromosome 4p, near the β1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number3
DOIs
StatePublished - May 8 1998

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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