Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays

Kenneth A. Marx; John Sharko; Georges G. Grinstein; Shannon Odelberg; Hans-Georg Simon

doi:10.1109/BIBE.2007.4375555

Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays

Kenneth A. Marx, John Sharko, Georges G. Grinstein, Shannon Odelberg, Hans-Georg Simon

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

We have studied newt (N. viridescens) gene expression levels in ∼ 1200 selected genes important in tissue regeneration at various times post-amputation at 6 different limb amputation sites. Here we provide analyses of microarray data that demonstrate a global gene expression correlation decrease on going from proximal to distal amputation sites of either limb or tail appendages. Also, the proximal (upper) forelimb and hindlimb regenerates have by far the most highly pairwise correlated gene expression levels of all sites. In contrast, the distal (lower) forelimb and hindlimb and tail regenerates reveal the least pairwise correlated gene expression levels. These data support the idea that limb loss at a proximal site produces afar more robust response as compared to a more distal site and requires a greater level of gene regulation to properly rebuild the lost structure.

Original language	English (US)
Title of host publication	Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
Pages	131-136
Number of pages	6
DOIs	https://doi.org/10.1109/BIBE.2007.4375555
State	Published - Dec 1 2007
Event	7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE - Boston, MA, United States Duration: Jan 14 2007 → Jan 17 2007

Other

Other	7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
Country	United States
City	Boston, MA
Period	1/14/07 → 1/17/07

ASJC Scopus subject areas

Biotechnology
Genetics
Bioengineering

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Marx, K. A., Sharko, J., Grinstein, G. G., Odelberg, S., & Simon, H-G. (2007). Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE (pp. 131-136). [4375555] https://doi.org/10.1109/BIBE.2007.4375555

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title = "Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays",

abstract = "We have studied newt (N. viridescens) gene expression levels in ∼ 1200 selected genes important in tissue regeneration at various times post-amputation at 6 different limb amputation sites. Here we provide analyses of microarray data that demonstrate a global gene expression correlation decrease on going from proximal to distal amputation sites of either limb or tail appendages. Also, the proximal (upper) forelimb and hindlimb regenerates have by far the most highly pairwise correlated gene expression levels of all sites. In contrast, the distal (lower) forelimb and hindlimb and tail regenerates reveal the least pairwise correlated gene expression levels. These data support the idea that limb loss at a proximal site produces afar more robust response as compared to a more distal site and requires a greater level of gene regulation to properly rebuild the lost structure.",

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Marx, KA, Sharko, J, Grinstein, GG, Odelberg, S & Simon, H-G 2007, Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays. in Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE., 4375555, pp. 131-136, 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE, Boston, MA, United States, 1/14/07. https://doi.org/10.1109/BIBE.2007.4375555

Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays. / Marx, Kenneth A.; Sharko, John; Grinstein, Georges G.; Odelberg, Shannon; Simon, Hans-Georg.

Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. p. 131-136 4375555.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Simon, Hans-Georg

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Evidence for proximal to distal appendage amputation site effects from global gene expression correlations found in newt microarrays

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