Evidence for Two Independent Factors that Modify Brain Networks to Meet Task Goals

Caterina Gratton*, Timothy O. Laumann, Evan M. Gordon, Babatunde Adeyemo, Steven E. Petersen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Humans easily and flexibly complete a wide variety of tasks. To accomplish this feat, the brain appears to subtly adjust stable brain networks. Here, we investigate what regional factors underlie these modifications, asking whether networks are either altered at (1) regions activated by a given task or (2) hubs that interconnect different networks. We used fMRI “functional connectivity” (FC) to compare networks during rest and three distinct tasks requiring semantic judgments, mental rotation, and visual coherence. We found that network modifications during these tasks were independently associated with both regional activation and network hubs. Furthermore, active and hub regions were associated with distinct patterns of network modification (differing in their localization, topography of FC changes, and variability across tasks), with activated hubs exhibiting patterns consistent with task control. These findings indicate that task goals modify brain networks through two separate processes linked to local brain function and network hubs.

Original languageEnglish (US)
Pages (from-to)1276-1288
Number of pages13
JournalCell reports
Volume17
Issue number5
DOIs
StatePublished - Oct 25 2016

Keywords

  • brain networks
  • fMRI
  • graph theory
  • task control

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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