Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory

Molly S. Hermiller*, Shruti Dave, Stephanie L. Wert, Stephen VanHaerents, Michaela Riley, Sandra Weintraub, M. Marsel Mesulam, Joel L. Voss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Episodic memory is supported by hippocampal interactions with a distributed network. Aging is associated with memory decline and network de-differentiation. However, the role of de-differentiation in memory decline has not been directly tested. We reasoned that hippocampal network-targeted stimulation could test these theories, as age-related changes in the network response to stimulation would indicate network reorganization, and corresponding changes in memory would suggest that this reorganization is functional. We compared effects of stimulation on fMRI connectivity and memory in younger versus older adults. Theta-burst network-targeted stimulation of left lateral parietal cortex selectively increased hippocampal network connectivity and modulated memory in younger adults. In contrast, stimulation in older adults increased connectivity throughout the brain, without network selectivity, and did not influence memory. These findings provide evidence that network responses to stimulation are de-differentiated in aging and suggest that age-related de-differentiation is relevant for memory. This manuscript is part of the Special Issue entitled “Cognitive Neuroscience of Healthy and Pathological Aging” edited by Drs. M. N. Rajah, S. Belleville, and R. Cabeza.

Original languageEnglish (US)
Pages (from-to)145-157
Number of pages13
JournalNeurobiology of Aging
Volume109
DOIs
StatePublished - Jan 2022

Keywords

  • Aging
  • Cognitive enhancement
  • Functional brain networks
  • Memory decline
  • Theta rhythm
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory'. Together they form a unique fingerprint.

Cite this