Evidence of a diurnal thermogenic handicap in obesity

Daniela Grimaldi, Federica Provini, Giulia Pierangeli, Natalia Mazzella, Giovanni Zamboni, Giulio Marchesini, Pietro Cortelli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A thermogenic handicap has been proposed as potential contributor to weight gain in obese subjects but results from clinical studies are inconclusive. We tested whether diurnal and nocturnal body core temperature (BcT) measured for 20-h differed in nine obese subjects compared with 12 lean healthy controls when studied at rest under strictly controlled conditions. BcT was significantly reduced (∼0.35C) in obese subjects only during diurnal hours while during nocturnal hours BcT pattern was identical in the two groups. Our preliminary data indicate that obesity is associated with a diurnal thermogenic handicap which could play a role in favoring weight gain by lowering whole-body energy expenditure.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalChronobiology International
Issue number2
StatePublished - Mar 1 2015


  • Body core temperature
  • Energy expenditure
  • Obesity
  • Resting metabolic rate
  • Thermogenesis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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