Evidence that purifying selection acts on promoter sequences

Robert K. Arthur, Ilya Ruvinsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.

Original languageEnglish (US)
Pages (from-to)1121-1126
Number of pages6
Issue number3
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Genetics


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