Evolution of a catabolic pathway in bacteria

S. A. Lerner*, T. T. Wu, E. C C Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Genetic derepression of ribitol dehydrogenase in a mutant of Aerobacter aerogenes, strain 1033, enabled it to grow on xylitol, a substrate of the enzyme, but not its inducer. A derivative strain with an improved rate of growth on xylitol was obtained from the first mutant. The faster growth rate was made possible by the production of an altered ribitol dehydrogenase, as demonstrated by an increase in its activity on xylitol relative to ribitol and by its decreased heat stability.

Original languageEnglish (US)
Pages (from-to)1313-1315
Number of pages3
Issue number3649
StatePublished - Jan 1 1964

ASJC Scopus subject areas

  • General


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