Evolution of Mitochondria as Signaling Organelles

Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

362 Scopus citations


Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that autonomously co-exist within the cell. However, the past two decades have provided evidence that mitochondria function as signaling organelles, constantly communicating with the cytosol to initiate biological events under homeostatic and stress conditions. Thus, the signaling function of the mitochondria may have been selected by nature from the inception of the early eukaryote, as discussed in this essay.

Original languageEnglish (US)
Pages (from-to)204-206
Number of pages3
JournalCell Metabolism
Issue number2
StatePublished - Aug 4 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Physiology
  • Cell Biology


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