Evolution of therapy for locally advanced rectal cancer

Nicole J. Altomare; Mary F. Mulcahy

doi:10.1002/jso.27531

Evolution of therapy for locally advanced rectal cancer

Nicole J. Altomare^*, Mary F. Mulcahy

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Rectal cancer is a prevalent disease worldwide. The standard treatment of locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy followed by surgery and adjuvant systemic chemotherapy. Studies have been done to determine the best sequence of treatments to improve survival, cure rate and long term toxicity profile. In this paper, we will review the literature regarding the evolution of LARC treatment.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Journal of surgical oncology
Volume	129
Issue number	1
DOIs	https://doi.org/10.1002/jso.27531
State	Published - Jan 2024

Keywords

Rectal neoplasms
chemoradiotherapy
immunotherapy
neoadjuvant therapy
organ preservation
radiotherapy

ASJC Scopus subject areas

Oncology
Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.27531

Cite this

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title = "Evolution of therapy for locally advanced rectal cancer",

abstract = "Rectal cancer is a prevalent disease worldwide. The standard treatment of locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy followed by surgery and adjuvant systemic chemotherapy. Studies have been done to determine the best sequence of treatments to improve survival, cure rate and long term toxicity profile. In this paper, we will review the literature regarding the evolution of LARC treatment.",

keywords = "Rectal neoplasms, chemoradiotherapy, immunotherapy, neoadjuvant therapy, organ preservation, radiotherapy",

author = "Altomare, {Nicole J.} and Mulcahy, {Mary F.}",

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AU - Mulcahy, Mary F.

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AB - Rectal cancer is a prevalent disease worldwide. The standard treatment of locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy followed by surgery and adjuvant systemic chemotherapy. Studies have been done to determine the best sequence of treatments to improve survival, cure rate and long term toxicity profile. In this paper, we will review the literature regarding the evolution of LARC treatment.

KW - Rectal neoplasms

KW - chemoradiotherapy

KW - immunotherapy

KW - neoadjuvant therapy

KW - organ preservation

KW - radiotherapy

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M3 - Review article

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ER -

Evolution of therapy for locally advanced rectal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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