TY - JOUR
T1 - Evolutionary expression of the neuronal form of the src protein in the brain
AU - Yang, X.
AU - Martinez, R.
AU - Le Beau, J.
AU - Wiestler, O.
AU - Walter, G.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - The protooncogene src encodes two proteins, designated pp60(c-src+) and pp60(c-src). pp60(c.src+) is expressed only in neurons, whereas pp60(c-src) is expressed in neuronal and nonneuronal cells. pp60(c-src+) differs from pp60(c-src) in that it contains in insert of 6 amino acids. To study the evolutionary conservation of the 6-amino acid insert, the expression of pp60(c-src+) in the brain of animals from different classes was assayed by using pp60(c-src+)-specific antibodies raised against a synthetic peptide corresponding to the insert. pp60(c-src+) was detected only in the brain of mammals, birds, and reptiles, but not amphibians and fish, whereas pp60(c-src) was present in the brain of all animals tested, including lobster (invertebrate). These findings indicate that pp60(c-src+) may play a role in events associated with higher brain function, such as neuronal plasticity.
AB - The protooncogene src encodes two proteins, designated pp60(c-src+) and pp60(c-src). pp60(c.src+) is expressed only in neurons, whereas pp60(c-src) is expressed in neuronal and nonneuronal cells. pp60(c-src+) differs from pp60(c-src) in that it contains in insert of 6 amino acids. To study the evolutionary conservation of the 6-amino acid insert, the expression of pp60(c-src+) in the brain of animals from different classes was assayed by using pp60(c-src+)-specific antibodies raised against a synthetic peptide corresponding to the insert. pp60(c-src+) was detected only in the brain of mammals, birds, and reptiles, but not amphibians and fish, whereas pp60(c-src) was present in the brain of all animals tested, including lobster (invertebrate). These findings indicate that pp60(c-src+) may play a role in events associated with higher brain function, such as neuronal plasticity.
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U2 - 10.1073/pnas.86.12.4751
DO - 10.1073/pnas.86.12.4751
M3 - Article
C2 - 2499890
AN - SCOPUS:0024389260
VL - 86
SP - 4751
EP - 4755
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 12
ER -