Evolving applications of fluorescence guided surgery in pediatric surgical oncology: A practical guide for surgeons

Seth D. Goldstein; Todd E. Heaton; Alexander Bondoc; Roshni Dasgupta; Abdelhafeez Abdelhafeez; Andrew M. Davidoff; Timothy B. Lautz

doi:10.1016/j.jpedsurg.2020.10.013

Evolving applications of fluorescence guided surgery in pediatric surgical oncology: A practical guide for surgeons

Seth D. Goldstein, Todd E. Heaton, Alexander Bondoc, Roshni Dasgupta, Abdelhafeez Abdelhafeez, Andrew M. Davidoff, Timothy B. Lautz^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Fluorescence-guided surgery (FGS) is an increasingly available and popular method of visual field augmentation. The basic premise of FGS entails injection of fluorescent indocyanine green (ICG) and subsequent detection with a near-infrared (NIR) camera. For pediatric surgical oncologists, FGS remains experimental but is a promising modality for identifying tumor margins, locating metastases, performing sentinel lymph node biopsies, protecting peritumoral structures of interest, and facilitating reconstruction. Familiarity with basic ICG pharmacokinetics and NIR detection optics is critical for surgeons wishing to judiciously use FGS, as its success is firmly grounded in a thorough understanding of its capabilities and limitations. In this practical guide, we outline several well-described and innovative FGS applications by disease type, including their methods of administration, modes of detection, and typical ICG dosing paradigms. Level of Evidence: V

Original language	English (US)
Pages (from-to)	215-223
Number of pages	9
Journal	Journal of pediatric surgery
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.jpedsurg.2020.10.013
State	Published - Feb 2021

Keywords

Fluorescence
Indocyanine green
Metastasectomy
Sentinel lymph node

ASJC Scopus subject areas

Surgery
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpedsurg.2020.10.013

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title = "Evolving applications of fluorescence guided surgery in pediatric surgical oncology: A practical guide for surgeons",

abstract = "Fluorescence-guided surgery (FGS) is an increasingly available and popular method of visual field augmentation. The basic premise of FGS entails injection of fluorescent indocyanine green (ICG) and subsequent detection with a near-infrared (NIR) camera. For pediatric surgical oncologists, FGS remains experimental but is a promising modality for identifying tumor margins, locating metastases, performing sentinel lymph node biopsies, protecting peritumoral structures of interest, and facilitating reconstruction. Familiarity with basic ICG pharmacokinetics and NIR detection optics is critical for surgeons wishing to judiciously use FGS, as its success is firmly grounded in a thorough understanding of its capabilities and limitations. In this practical guide, we outline several well-described and innovative FGS applications by disease type, including their methods of administration, modes of detection, and typical ICG dosing paradigms. Level of Evidence: V",

keywords = "Fluorescence, Indocyanine green, Metastasectomy, Sentinel lymph node",

author = "Goldstein, {Seth D.} and Heaton, {Todd E.} and Alexander Bondoc and Roshni Dasgupta and Abdelhafeez Abdelhafeez and Davidoff, {Andrew M.} and Lautz, {Timothy B.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

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language = "English (US)",

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T2 - A practical guide for surgeons

AU - Goldstein, Seth D.

AU - Heaton, Todd E.

AU - Bondoc, Alexander

AU - Dasgupta, Roshni

AU - Abdelhafeez, Abdelhafeez

AU - Davidoff, Andrew M.

AU - Lautz, Timothy B.

PY - 2021/2

Y1 - 2021/2

N2 - Fluorescence-guided surgery (FGS) is an increasingly available and popular method of visual field augmentation. The basic premise of FGS entails injection of fluorescent indocyanine green (ICG) and subsequent detection with a near-infrared (NIR) camera. For pediatric surgical oncologists, FGS remains experimental but is a promising modality for identifying tumor margins, locating metastases, performing sentinel lymph node biopsies, protecting peritumoral structures of interest, and facilitating reconstruction. Familiarity with basic ICG pharmacokinetics and NIR detection optics is critical for surgeons wishing to judiciously use FGS, as its success is firmly grounded in a thorough understanding of its capabilities and limitations. In this practical guide, we outline several well-described and innovative FGS applications by disease type, including their methods of administration, modes of detection, and typical ICG dosing paradigms. Level of Evidence: V

AB - Fluorescence-guided surgery (FGS) is an increasingly available and popular method of visual field augmentation. The basic premise of FGS entails injection of fluorescent indocyanine green (ICG) and subsequent detection with a near-infrared (NIR) camera. For pediatric surgical oncologists, FGS remains experimental but is a promising modality for identifying tumor margins, locating metastases, performing sentinel lymph node biopsies, protecting peritumoral structures of interest, and facilitating reconstruction. Familiarity with basic ICG pharmacokinetics and NIR detection optics is critical for surgeons wishing to judiciously use FGS, as its success is firmly grounded in a thorough understanding of its capabilities and limitations. In this practical guide, we outline several well-described and innovative FGS applications by disease type, including their methods of administration, modes of detection, and typical ICG dosing paradigms. Level of Evidence: V

KW - Fluorescence

KW - Indocyanine green

KW - Metastasectomy

KW - Sentinel lymph node

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Evolving applications of fluorescence guided surgery in pediatric surgical oncology: A practical guide for surgeons

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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