Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management

Ilana Nazari, Matthew J. Feinstein*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

People with HIV (PWH) are at elevated risk for cardiovascular diseases (CVDs), including myocardial infarction, heart failure, and sudden cardiac death, among other CVD manifestations. Chronic immune dysregulation resulting in persistent inflammation is common among PWH, particularly those with sustained viremia and impaired CD4+ T cell recovery. This inflammatory milieu is a major contributor to CVDs among PWH, in concert with common comorbidities (such as dyslipidemia and smoking) and, to a lesser extent, off-target effects of antiretroviral therapy. In this review, we discuss the clinical and mechanistic evidence surrounding heightened CVD risks among PWH, implications for specific CVD manifestations, and practical guidance for management in the setting of evolving data.

Original languageEnglish (US)
JournalClinical microbiology reviews
Volume37
Issue number1
DOIs
StatePublished - Mar 2024

Keywords

  • cardiovascular disease
  • human immunodeficiency virus
  • inflammation

ASJC Scopus subject areas

  • General Medicine

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