EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model

Kichang Han, Jung Hoon Park, Su Geun Yang*, Deok Hee Lee, Jiaywei Tsauo, Kun Yung Kim, Min Tae Kim, Sung Gwon Gang, Dae Kee Kim, Dong Hyun Kim, Ho Young Song

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose To evaluate an EW-7197-eluting nanofiber-covered stent (NFCS) for suppressing granulation tissue formation after stent placement in a canine urethral model. Materials and methods All experiments were approved by the committee of animal research. A total of 12 NFCSs were placed in the proximal and distal urethras of six dogs. Dogs were divided into two groups with 3 dogs each. The control stent (CS) group received NFCSs and the drug stent (DS) group received EW-7197 (1000 μg)-eluting NFCSs. All dogs were sacrificed 8 weeks after stent placement Histologic findings of the stented urethra were compared using the Mann-Whitney U test. Results Stent placement was technically successful in all dogs without procedure-related complications. On urethrographic analysis, the mean luminal diameter was significantly larger in the DS group than in the CS group at 4 and 8 weeks after stent placement (all p < 0.001). On histological examination, mean thicknesses of the papillary projection, thickness of submucosal fibrosis, number of epithelial layers, and degree of collagen deposition were significantly lower in the DS group than in the CS group (all p < 0.001), whereas the mean degree of inflammatory cell infiltration was not significantly different (p > 0.05). Conclusion The EW-7197-eluting NFCS is effective and safe for suppressing granulation tissue formation after stent placement in a canine urethral model.

Original languageEnglish (US)
Article numbere0192430
JournalPloS one
Volume13
Issue number2
DOIs
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Han, K., Park, J. H., Yang, S. G., Lee, D. H., Tsauo, J., Kim, K. Y., Kim, M. T., Gang, S. G., Kim, D. K., Kim, D. H., & Song, H. Y. (2018). EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model. PloS one, 13(2), [e0192430]. https://doi.org/10.1371/journal.pone.0192430