Ewing sarcoma: A 15-year experience of a single Center with the MSKCC P6 treatment protocol

Tal Ben-Ami*, Elisha Waldman, Wygoda Marc, Michael Weintraub, Shoshana Revel-Vilk, Iris Fried

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Ewing sarcoma (ES) is the second most common bone tumor in children. Current chemotherapeutic regimens include high-dose anthracyclines and alkylating agents with significant variation in treatment length. The Memorial Sloan Kettering Cancer Center P6 regimen (MSKCC P6) treatment protocol is a highly aggressive regimen given over 21 weeks only. We present the outcome of ES patients treated in our center with this protocol over the last 15 years. Procedure: We retrospectively analyzed data on the presentation, patient characteristics, treatment, and outcome of all ES patients treated according to the MSKCC P6 regimen from 1999 to 2014. Results: Of 48 patients, 37 (77%) presented with a nonmetastatic disease and 26 (54%) with tumor located in the extremities. The 5-year overall survival (OS) of the entire cohort was 55.9%±8%. Nonmetastatic disease conferred a better prognosis with a 5-year OS of 68.4%±8.5%. Patients with a nonmetastatic extremity tumor had the most favorable outcome with 5-year OS of 72.2%±9.8%. Conclusion: The outcome of ES patients after a short aggressive course of chemotherapy (the MSKCC P6 protocol), is comparable to that following other first-line treatment regimens in use, with potentially fewer long-term adverse events.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalJournal of pediatric hematology/oncology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Chemotherapy
  • Ewing sarcoma
  • Outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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