@inproceedings{4dd02b5f255b44c8a4bd9265582713aa,
title = "Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies",
abstract = "Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (A{\ss}P) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased A{\ss}P and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced A{\ss}P and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.",
keywords = "Alzheimer's disease, Brain pathology, Cerebrolysin, Concussive head injury, Hot environment, Neuroprotection, Tau antibodies, TiO2 nanowired delivery",
author = "Sharma, {Hari Shanker} and Lafuente, {Jos{\'e} V.} and Muresanu, {Dafin F.} and Castellani, {Rudy J.} and Smith, {Mark A.} and Ala Nozari and Ranjana Patnaik and Tian, {Z. Ryan} and Asya Ozkizilcik and Herbert M{\"o}ssier and Aruna Sharma",
note = "Funding Information: Supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; supported by Grants from the Alzheimer's Association (IIRG-09-132087), the National Institutes of Health (ROI AG028679) and the Dr. Robert M. Kohrman Memorial Fund (MAS, RJC); Swedish Medical Research Council (Nr 2710-HSS), G{\"o}ran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, M{\"o}lndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt, of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT 794/13 (JVL), Government of Basque Country and UFI 11/32 (JVL) University of Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Technical and human support provided by Dr Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Uppsala, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. Publisher Copyright: {\textcopyright} 2018 OOSV. All rights reserved.; 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference ; Conference date: 13-05-2018 Through 16-05-2018",
year = "2018",
language = "English (US)",
series = "TechConnect Briefs 2018 - Advanced Materials",
publisher = "TechConnect",
pages = "73--76",
editor = "Bart Romanowicz and Fiona Case and Fiona Case and Matthew Laudon",
booktitle = "TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical",
}