Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Hari Shanker Sharma, José V. Lafuente, Dafin F. Muresanu, Rudy J. Castellani, Mark A. Smith, Ala Nozari, Ranjana Patnaik, Z. Ryan Tian, Asya Ozkizilcik, Herbert Mössier, Aruna Sharma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (AßP) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased AßP and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced AßP and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.

Original languageEnglish (US)
Title of host publicationTechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical
EditorsBart Romanowicz, Fiona Case, Fiona Case, Matthew Laudon
PublisherTechConnect
Pages73-76
Number of pages4
ISBN (Electronic)9780998878249
StatePublished - 2018
Externally publishedYes
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference - Anaheim, United States
Duration: May 13 2018May 16 2018

Publication series

NameTechConnect Briefs 2018 - Advanced Materials
Volume3

Other

Other11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference
Country/TerritoryUnited States
CityAnaheim
Period5/13/185/16/18

Keywords

  • Alzheimer's disease
  • Brain pathology
  • Cerebrolysin
  • Concussive head injury
  • Hot environment
  • Neuroprotection
  • Tau antibodies
  • TiO2 nanowired delivery

ASJC Scopus subject areas

  • Materials Science(all)

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