Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Hari Shanker Sharma; José V. Lafuente; Dafin F. Muresanu; Rudy J. Castellani; Mark A. Smith; Ala Nozari; Ranjana Patnaik; Z. Ryan Tian; Asya Ozkizilcik; Herbert Mössier; Aruna Sharma

Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Hari Shanker Sharma, José V. Lafuente, Dafin F. Muresanu, Rudy J. Castellani, Mark A. Smith, Ala Nozari, Ranjana Patnaik, Z. Ryan Tian, Asya Ozkizilcik, Herbert Mössier, Aruna Sharma

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (AßP) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased AßP and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced AßP and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.

Original language	English (US)
Title of host publication	TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical
Editors	Bart Romanowicz, Fiona Case, Fiona Case, Matthew Laudon
Publisher	TechConnect
Pages	73-76
Number of pages	4
ISBN (Electronic)	9780998878249
State	Published - 2018
Event	11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference - Anaheim, United States Duration: May 13 2018 → May 16 2018

Publication series

Name	TechConnect Briefs 2018 - Advanced Materials
Volume	3

Other

Other	11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference
Country/Territory	United States
City	Anaheim
Period	5/13/18 → 5/16/18

Funding

Supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; supported by Grants from the Alzheimer's Association (IIRG-09-132087), the National Institutes of Health (ROI AG028679) and the Dr. Robert M. Kohrman Memorial Fund (MAS, RJC); Swedish Medical Research Council (Nr 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, Mölndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt, of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT 794/13 (JVL), Government of Basque Country and UFI 11/32 (JVL) University of Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Technical and human support provided by Dr Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Uppsala, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government.

Keywords

Alzheimer's disease
Brain pathology
Cerebrolysin
Concussive head injury
Hot environment
Neuroprotection
Tau antibodies
TiO2 nanowired delivery

ASJC Scopus subject areas

General Materials Science

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Sharma, H. S., Lafuente, J. V., Muresanu, D. F., Castellani, R. J., Smith, M. A., Nozari, A., Patnaik, R., Tian, Z. R., Ozkizilcik, A., Mössier, H., & Sharma, A. (2018). Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies. In B. Romanowicz, F. Case, F. Case, & M. Laudon (Eds.), TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical (pp. 73-76). (TechConnect Briefs 2018 - Advanced Materials; Vol. 3). TechConnect.

Sharma, Hari Shanker ; Lafuente, José V. ; Muresanu, Dafin F. et al. / Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies. TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical. editor / Bart Romanowicz ; Fiona Case ; Fiona Case ; Matthew Laudon. TechConnect, 2018. pp. 73-76 (TechConnect Briefs 2018 - Advanced Materials).

@inproceedings{4dd02b5f255b44c8a4bd9265582713aa,

title = "Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies",

abstract = "Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (A{\ss}P) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased A{\ss}P and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced A{\ss}P and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.",

keywords = "Alzheimer's disease, Brain pathology, Cerebrolysin, Concussive head injury, Hot environment, Neuroprotection, Tau antibodies, TiO2 nanowired delivery",

author = "Sharma, {Hari Shanker} and Lafuente, {Jos{\'e} V.} and Muresanu, {Dafin F.} and Castellani, {Rudy J.} and Smith, {Mark A.} and Ala Nozari and Ranjana Patnaik and Tian, {Z. Ryan} and Asya Ozkizilcik and Herbert M{\"o}ssier and Aruna Sharma",

note = "Publisher Copyright: {\textcopyright} 2018 OOSV. All rights reserved.; 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference ; Conference date: 13-05-2018 Through 16-05-2018",

year = "2018",

language = "English (US)",

series = "TechConnect Briefs 2018 - Advanced Materials",

publisher = "TechConnect",

pages = "73--76",

editor = "Bart Romanowicz and Fiona Case and Fiona Case and Matthew Laudon",

booktitle = "TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical",

}

Sharma, HS, Lafuente, JV, Muresanu, DF, Castellani, RJ, Smith, MA, Nozari, A, Patnaik, R, Tian, ZR, Ozkizilcik, A, Mössier, H & Sharma, A 2018, Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies. in B Romanowicz, F Case, F Case & M Laudon (eds), TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical. TechConnect Briefs 2018 - Advanced Materials, vol. 3, TechConnect, pp. 73-76, 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference, Anaheim, United States, 5/13/18.

Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies. / Sharma, Hari Shanker; Lafuente, José V.; Muresanu, Dafin F. et al.
TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical. ed. / Bart Romanowicz; Fiona Case; Fiona Case; Matthew Laudon. TechConnect, 2018. p. 73-76 (TechConnect Briefs 2018 - Advanced Materials; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

AU - Sharma, Hari Shanker

AU - Lafuente, José V.

AU - Muresanu, Dafin F.

AU - Castellani, Rudy J.

AU - Smith, Mark A.

AU - Nozari, Ala

AU - Patnaik, Ranjana

AU - Tian, Z. Ryan

AU - Ozkizilcik, Asya

AU - Mössier, Herbert

AU - Sharma, Aruna

PY - 2018

Y1 - 2018

N2 - Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (AßP) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased AßP and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced AßP and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.

AB - Military personnel are prone to develop Alzheimer's disease (AD) during their lifetime. This is attributed largely due to mild traumatic brain injury, stress, hyperthermia and exposure to nanoparticles or chemical fumes during combat operations. All these conditions could induce breakdown of the blood-brain barrier (BBB) and edema formation. BBB breakdowm will allow plasma amyloid beta protein (AßP) to enter into the brain parenchyma and lead to slowy developing AD. Cievage of amyloid precursor proetin (APP) leads to tau phosporylation that is toxic to neurons and participate in AD process. In present innovation we demonstrate that concussive head injury (CHI) results in increased AßP and tau proetins in the cerebrosoinal fluid (CSF) of rats. This effect is exacerbated in hot environment (HE). As a result, brain pathology, BBB breakdown and edema formation are also exacerbated after CHI in HE. It appears that TiO2-nanwored delivery of cerebrolysin together with antibodies to tau remarkably reduced AßP and tau concetrations in the CSF and induced neuroprotection. This indicates that nanodelivery of cerebrolysin with tau antibodies has supeior neuroprotective ability in CHI, not reported earlier.

KW - Alzheimer's disease

KW - Brain pathology

KW - Cerebrolysin

KW - Concussive head injury

KW - Hot environment

KW - Neuroprotection

KW - Tau antibodies

KW - TiO2 nanowired delivery

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T3 - TechConnect Briefs 2018 - Advanced Materials

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BT - TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical

A2 - Romanowicz, Bart

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PB - TechConnect

T2 - 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference

Y2 - 13 May 2018 through 16 May 2018

ER -

Sharma HS, Lafuente JV, Muresanu DF, Castellani RJ, Smith MA, Nozari A et al. Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies. In Romanowicz B, Case F, Case F, Laudon M, editors, TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical. TechConnect. 2018. p. 73-76. (TechConnect Briefs 2018 - Advanced Materials).

Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Abstract

Publication series

Other

Funding

Keywords

ASJC Scopus subject areas

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