Exaggerated Radiation-Induced Fibrosis in Patients With Systemic Sclerosis

John Varga, U. F. Haustein, Richard H. Creech, James P. Dwyer, Sergio A. Jimenez*

*Corresponding author for this work

Research output: Contribution to journalArticle

93 Scopus citations


Four patients with stable systemic sclerosis and limited skin involvement received radiation for the treatment of solid malignant neoplasms. Following localized irradiation, each patient developed an exaggerated cutaneous and internal fibrotic reaction in the irradiated areas. The surface area of fibrosis extended beyond the radiation portals employed, and the fibrotic process was poorly responsive to antifibrotic therapy. Three of the patients died of complications caused by fibrous encasement of internal organs. The extent and severity of postradiation fibrosis in these patients was distinctly unusual. These observations suggest that patients with systemic sclerosis are particularly susceptible to developing excessive radiation-induced fibrosis.

Original languageEnglish (US)
Pages (from-to)3292-3295
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number24
StatePublished - Jun 26 1991

ASJC Scopus subject areas

  • Medicine(all)

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