TY - JOUR
T1 - Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma
AU - Sherman, Karen L.
AU - Kinnier, Christine V.
AU - Farina, Domenico A.
AU - Wayne, Jeffrey D.
AU - Laskin, William B.
AU - Agulnik, Mark
AU - Attar, Samer
AU - Hayes, John P.
AU - Peabody, Terrance
AU - Bilimoria, Karl Y.
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Methods: ESTS patients from the National Cancer Data Base (2000.2009) were assessed, and regression models were used to identify factors associated with nodal evaluation and metastases.Results: Of 27,536 ESTS patients, 1,924 (7%) underwent nodal evaluation, and of these, 290 (15%) had nodal metastases. Nodal evaluation was most frequently performed for rhabdomyosarcoma (15.6%), angiosarcoma (10.0%), clear cell sarcoma (39.3%), epithelioid sarcoma (28.1%), and synovial sarcoma (9.3%). On multivariable analysis, factors associated with nodal evaluation included histologic subtype, tumor size, and grade. Nodal metastasis rates were highest among patients with rhabdomyosarcoma (32.1%), angiosarcoma (24.1%), clear cell sarcoma (27.7%), and epithelioid sarcoma (31.8%). On multivariable analysis, factors associated with nodal metastases included histologic subtype, tumor size, and grade.Conclusions: Nodal evaluation rates are highest among certain expected subtypes but are generally low. However, nodal metastasis rates for many histologic subtypes in patients selected for lymph node evaluation may be higher than previously reported. Multi-institutional studies should address nodal evaluation for ESTS.Background and Objectives: Lymph node evaluation recommendations for extremity soft tissue sarcoma (ESTS) are absent from national guidelines. Our objectives were (1) to assess rates and predictors of nodal evaluation, and (2) to assess rates and predictors of nodal metastases.
AB - Methods: ESTS patients from the National Cancer Data Base (2000.2009) were assessed, and regression models were used to identify factors associated with nodal evaluation and metastases.Results: Of 27,536 ESTS patients, 1,924 (7%) underwent nodal evaluation, and of these, 290 (15%) had nodal metastases. Nodal evaluation was most frequently performed for rhabdomyosarcoma (15.6%), angiosarcoma (10.0%), clear cell sarcoma (39.3%), epithelioid sarcoma (28.1%), and synovial sarcoma (9.3%). On multivariable analysis, factors associated with nodal evaluation included histologic subtype, tumor size, and grade. Nodal metastasis rates were highest among patients with rhabdomyosarcoma (32.1%), angiosarcoma (24.1%), clear cell sarcoma (27.7%), and epithelioid sarcoma (31.8%). On multivariable analysis, factors associated with nodal metastases included histologic subtype, tumor size, and grade.Conclusions: Nodal evaluation rates are highest among certain expected subtypes but are generally low. However, nodal metastasis rates for many histologic subtypes in patients selected for lymph node evaluation may be higher than previously reported. Multi-institutional studies should address nodal evaluation for ESTS.Background and Objectives: Lymph node evaluation recommendations for extremity soft tissue sarcoma (ESTS) are absent from national guidelines. Our objectives were (1) to assess rates and predictors of nodal evaluation, and (2) to assess rates and predictors of nodal metastases.
KW - Lymph node excision
KW - Lymphatic metastasis
KW - Neoplasms
KW - Retrospective studies
UR - http://www.scopus.com/inward/record.url?scp=84912036534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912036534&partnerID=8YFLogxK
U2 - 10.1002/jso.23687
DO - 10.1002/jso.23687
M3 - Article
C2 - 24910401
AN - SCOPUS:84912036534
VL - 110
SP - 682
EP - 688
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 6
ER -
