Examining the role of the tectorial membrane in otoacoustic emission generation

Mary Ann Cheatham, Richard J. Goodyear, Karolina K. Charaziak, Tess Conklin, Jing Zheng, Peter Dallos, Guy P. Richardson, Jonathan H Siegel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mouse lacking CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of proteins, shows changes in tectorial membrane (TM) structure including loss of a defined striated-sheet matrix, absence of Hensen's stripe and increased porosity. In spite of these changes, thresholds for distortion product emissions (DPOAEs) and auditory brainstem responses (ABR) are near normal for most frequencies in the mouse audiogram [11]. In contrast, stimulus frequency emissions (SFOAE) are larger in knockouts (KO) and the incidence of spontaneous emissions (SOAE) is ∼70% [5]. This latter statistic is remarkable considering that SOAEs are uncommon in normal wild-type (WT) mice. In order to understand how the TM might influence emissions, SFOAE magnitude and phase were examined and group delays computed. As in humans, an approximately one-cycle phase change is observed in association with SFOAE fine structure. In addition, CEACAM16 KO mice and their WT controls showed similar group delays/phase slopes indicating no obvious changes in the mechanisms associated with emission generation.

Original languageEnglish (US)
Title of host publicationMechanics of Hearing
Subtitle of host publicationProtein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing
EditorsDavid P. Corey, K. Domenica Karavitaki
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413504
DOIs
StatePublished - Dec 31 2015
Event12th International Workshop on the Mechanics of Hearing: Protein to Perception - Cape Sounio, Greece
Duration: Jun 23 2014Jun 29 2014

Publication series

NameAIP Conference Proceedings
Volume1703
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other12th International Workshop on the Mechanics of Hearing: Protein to Perception
CountryGreece
CityCape Sounio
Period6/23/146/29/14

Fingerprint

membranes
mice
knockout mice
membrane structures
antigens
stimuli
spontaneous emission
adhesion
incidence
fine structure
statistics
slopes
proteins
porosity
cycles
thresholds
products
matrices
cells
molecules

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • Physics and Astronomy(all)
  • Nature and Landscape Conservation

Cite this

Cheatham, M. A., Goodyear, R. J., Charaziak, K. K., Conklin, T., Zheng, J., Dallos, P., ... Siegel, J. H. (2015). Examining the role of the tectorial membrane in otoacoustic emission generation. In D. P. Corey, & K. D. Karavitaki (Eds.), Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing [090005] (AIP Conference Proceedings; Vol. 1703). American Institute of Physics Inc.. https://doi.org/10.1063/1.4939403
Cheatham, Mary Ann ; Goodyear, Richard J. ; Charaziak, Karolina K. ; Conklin, Tess ; Zheng, Jing ; Dallos, Peter ; Richardson, Guy P. ; Siegel, Jonathan H. / Examining the role of the tectorial membrane in otoacoustic emission generation. Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. editor / David P. Corey ; K. Domenica Karavitaki. American Institute of Physics Inc., 2015. (AIP Conference Proceedings).
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title = "Examining the role of the tectorial membrane in otoacoustic emission generation",
abstract = "A mouse lacking CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of proteins, shows changes in tectorial membrane (TM) structure including loss of a defined striated-sheet matrix, absence of Hensen's stripe and increased porosity. In spite of these changes, thresholds for distortion product emissions (DPOAEs) and auditory brainstem responses (ABR) are near normal for most frequencies in the mouse audiogram [11]. In contrast, stimulus frequency emissions (SFOAE) are larger in knockouts (KO) and the incidence of spontaneous emissions (SOAE) is ∼70{\%} [5]. This latter statistic is remarkable considering that SOAEs are uncommon in normal wild-type (WT) mice. In order to understand how the TM might influence emissions, SFOAE magnitude and phase were examined and group delays computed. As in humans, an approximately one-cycle phase change is observed in association with SFOAE fine structure. In addition, CEACAM16 KO mice and their WT controls showed similar group delays/phase slopes indicating no obvious changes in the mechanisms associated with emission generation.",
author = "Cheatham, {Mary Ann} and Goodyear, {Richard J.} and Charaziak, {Karolina K.} and Tess Conklin and Jing Zheng and Peter Dallos and Richardson, {Guy P.} and Siegel, {Jonathan H}",
year = "2015",
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language = "English (US)",
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Cheatham, MA, Goodyear, RJ, Charaziak, KK, Conklin, T, Zheng, J, Dallos, P, Richardson, GP & Siegel, JH 2015, Examining the role of the tectorial membrane in otoacoustic emission generation. in DP Corey & KD Karavitaki (eds), Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing., 090005, AIP Conference Proceedings, vol. 1703, American Institute of Physics Inc., 12th International Workshop on the Mechanics of Hearing: Protein to Perception, Cape Sounio, Greece, 6/23/14. https://doi.org/10.1063/1.4939403

Examining the role of the tectorial membrane in otoacoustic emission generation. / Cheatham, Mary Ann; Goodyear, Richard J.; Charaziak, Karolina K.; Conklin, Tess; Zheng, Jing; Dallos, Peter; Richardson, Guy P.; Siegel, Jonathan H.

Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. ed. / David P. Corey; K. Domenica Karavitaki. American Institute of Physics Inc., 2015. 090005 (AIP Conference Proceedings; Vol. 1703).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Examining the role of the tectorial membrane in otoacoustic emission generation

AU - Cheatham, Mary Ann

AU - Goodyear, Richard J.

AU - Charaziak, Karolina K.

AU - Conklin, Tess

AU - Zheng, Jing

AU - Dallos, Peter

AU - Richardson, Guy P.

AU - Siegel, Jonathan H

PY - 2015/12/31

Y1 - 2015/12/31

N2 - A mouse lacking CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of proteins, shows changes in tectorial membrane (TM) structure including loss of a defined striated-sheet matrix, absence of Hensen's stripe and increased porosity. In spite of these changes, thresholds for distortion product emissions (DPOAEs) and auditory brainstem responses (ABR) are near normal for most frequencies in the mouse audiogram [11]. In contrast, stimulus frequency emissions (SFOAE) are larger in knockouts (KO) and the incidence of spontaneous emissions (SOAE) is ∼70% [5]. This latter statistic is remarkable considering that SOAEs are uncommon in normal wild-type (WT) mice. In order to understand how the TM might influence emissions, SFOAE magnitude and phase were examined and group delays computed. As in humans, an approximately one-cycle phase change is observed in association with SFOAE fine structure. In addition, CEACAM16 KO mice and their WT controls showed similar group delays/phase slopes indicating no obvious changes in the mechanisms associated with emission generation.

AB - A mouse lacking CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of proteins, shows changes in tectorial membrane (TM) structure including loss of a defined striated-sheet matrix, absence of Hensen's stripe and increased porosity. In spite of these changes, thresholds for distortion product emissions (DPOAEs) and auditory brainstem responses (ABR) are near normal for most frequencies in the mouse audiogram [11]. In contrast, stimulus frequency emissions (SFOAE) are larger in knockouts (KO) and the incidence of spontaneous emissions (SOAE) is ∼70% [5]. This latter statistic is remarkable considering that SOAEs are uncommon in normal wild-type (WT) mice. In order to understand how the TM might influence emissions, SFOAE magnitude and phase were examined and group delays computed. As in humans, an approximately one-cycle phase change is observed in association with SFOAE fine structure. In addition, CEACAM16 KO mice and their WT controls showed similar group delays/phase slopes indicating no obvious changes in the mechanisms associated with emission generation.

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M3 - Conference contribution

T3 - AIP Conference Proceedings

BT - Mechanics of Hearing

A2 - Corey, David P.

A2 - Karavitaki, K. Domenica

PB - American Institute of Physics Inc.

ER -

Cheatham MA, Goodyear RJ, Charaziak KK, Conklin T, Zheng J, Dallos P et al. Examining the role of the tectorial membrane in otoacoustic emission generation. In Corey DP, Karavitaki KD, editors, Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. American Institute of Physics Inc. 2015. 090005. (AIP Conference Proceedings). https://doi.org/10.1063/1.4939403