Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: A case report and literature review

Young Kwang Chae*, Naira Saleem, Yoonhwan Roh, Haris Bilal, Pedro Viveiros, Bhoomika Sukhadia, Xiaoqi Lin, Muhammad Mubbashir Sheikh, Lee Chun Park

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment. Case presentation: We describe a unique case of PRSA in a 71-year-old male who presented with right-sided lower back pain and numbness. Magnetic resonance imaging identified a mass invading the adjacent psoas muscle and twelfth rib. Tissue biopsy confirmed poorly differentiated PRSA. Patient was initially treated with neoadjuvant carboplatin and paclitaxel chemotherapy regimen. This resulted in complete radiological resolution of the tumor. However, 12 weeks later, rapid recurrence was noted on follow-up CT scan. The patient was then treated with external radiotherapy with concurrent nivolumab, an anti-PD-1 antibody. The patient displayed a positive response to treatment with reduction in primary tumor and metastases and had a sustained disease control. Conclusion: Treatment with radiotherapy in combination with anti-PD-1 antibody could be an effective modality of management for PRSA.

Original languageEnglish (US)
Article number748
JournalBMC cancer
Volume19
Issue number1
DOIs
StatePublished - Jul 30 2019

Keywords

  • Chemotherapy
  • Nivolumab
  • PRSA
  • Primary retroperitoneal serous adenocarcinoma
  • Radiotherapy

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

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