Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women

Carlos A. Carreno*, Rebecca G. Clifton, John C. Hauth, Leslie Myatt, James M. Roberts, Catherine Y. Spong, Michael W. Varner, John M. Thorp, Brian M. Mercer, Alan M Peaceman, Susan M. Ramin, Marshall W. Carpenter, Anthony Sciscione, Jorge E. Tolosa, Yoram Sorokin

*Corresponding author for this work

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Objective: To estimate whether there is an association between excessive early gestational weight gain and the development of gestational diabetes mellitus (GDM) and excessive fetal growth. Methods: This is a secondary analysis of a randomized controlled trial of vitamins C and E in nulliparous low-risk women. Maternal weight gain from prepregnancy (self-reported) to 15-18 weeks of gestation was measured, and expected gestational weight gain was determined using the Institute of Medicine 2009 guidelines for each prepregnancy body mass index category. Excessive early gestational weight gain was defined as gestational weight gain greater than the upper range of the Institute of Medicine guidelines. Rates of GDM, birth weight greater than 4,000 g, and large for gestational age (LGA, birth weight 90 percentile or higher) were calculated and compared between women with excessive early gestational weight gain and early nonexcessive gestational weight gain (within or below Institute of Medicine guidelines). Results: A total of 7,985 women were studied. Excessive early gestational weight gain occurred in 47.5% of women. Ninety-three percent of women with excessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines. In contrast, only 55% of women with nonexcessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines (P<.001). Rates of GDM, LGA, and birth weight greater than 4,000 g were higher in women with excessive early gestational weight gain. Conclusion: In our population, excessive early gestational weight gain occurred in 93% of women who had total gestational weight gain greater than the Institute of Medicine guidelines. In low-risk nulliparous women, excessive early gestational weight gain is associated with the development of GDM and excessive fetal growth.

Original languageEnglish (US)
Pages (from-to)1227-1233
Number of pages7
JournalObstetrics and Gynecology
Volume119
Issue number6
DOIs
StatePublished - Jun 1 2012

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Gestational Diabetes
Weight Gain
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Guidelines
Birth Weight
Fetal Development
Vitamin E

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Carreno, C. A., Clifton, R. G., Hauth, J. C., Myatt, L., Roberts, J. M., Spong, C. Y., ... Sorokin, Y. (2012). Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women. Obstetrics and Gynecology, 119(6), 1227-1233. https://doi.org/10.1097/AOG.0b013e318256cf1a
Carreno, Carlos A. ; Clifton, Rebecca G. ; Hauth, John C. ; Myatt, Leslie ; Roberts, James M. ; Spong, Catherine Y. ; Varner, Michael W. ; Thorp, John M. ; Mercer, Brian M. ; Peaceman, Alan M ; Ramin, Susan M. ; Carpenter, Marshall W. ; Sciscione, Anthony ; Tolosa, Jorge E. ; Sorokin, Yoram. / Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women. In: Obstetrics and Gynecology. 2012 ; Vol. 119, No. 6. pp. 1227-1233.
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abstract = "Objective: To estimate whether there is an association between excessive early gestational weight gain and the development of gestational diabetes mellitus (GDM) and excessive fetal growth. Methods: This is a secondary analysis of a randomized controlled trial of vitamins C and E in nulliparous low-risk women. Maternal weight gain from prepregnancy (self-reported) to 15-18 weeks of gestation was measured, and expected gestational weight gain was determined using the Institute of Medicine 2009 guidelines for each prepregnancy body mass index category. Excessive early gestational weight gain was defined as gestational weight gain greater than the upper range of the Institute of Medicine guidelines. Rates of GDM, birth weight greater than 4,000 g, and large for gestational age (LGA, birth weight 90 percentile or higher) were calculated and compared between women with excessive early gestational weight gain and early nonexcessive gestational weight gain (within or below Institute of Medicine guidelines). Results: A total of 7,985 women were studied. Excessive early gestational weight gain occurred in 47.5{\%} of women. Ninety-three percent of women with excessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines. In contrast, only 55{\%} of women with nonexcessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines (P<.001). Rates of GDM, LGA, and birth weight greater than 4,000 g were higher in women with excessive early gestational weight gain. Conclusion: In our population, excessive early gestational weight gain occurred in 93{\%} of women who had total gestational weight gain greater than the Institute of Medicine guidelines. In low-risk nulliparous women, excessive early gestational weight gain is associated with the development of GDM and excessive fetal growth.",
author = "Carreno, {Carlos A.} and Clifton, {Rebecca G.} and Hauth, {John C.} and Leslie Myatt and Roberts, {James M.} and Spong, {Catherine Y.} and Varner, {Michael W.} and Thorp, {John M.} and Mercer, {Brian M.} and Peaceman, {Alan M} and Ramin, {Susan M.} and Carpenter, {Marshall W.} and Anthony Sciscione and Tolosa, {Jorge E.} and Yoram Sorokin",
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Carreno, CA, Clifton, RG, Hauth, JC, Myatt, L, Roberts, JM, Spong, CY, Varner, MW, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Sciscione, A, Tolosa, JE & Sorokin, Y 2012, 'Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women', Obstetrics and Gynecology, vol. 119, no. 6, pp. 1227-1233. https://doi.org/10.1097/AOG.0b013e318256cf1a

Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women. / Carreno, Carlos A.; Clifton, Rebecca G.; Hauth, John C.; Myatt, Leslie; Roberts, James M.; Spong, Catherine Y.; Varner, Michael W.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M; Ramin, Susan M.; Carpenter, Marshall W.; Sciscione, Anthony; Tolosa, Jorge E.; Sorokin, Yoram.

In: Obstetrics and Gynecology, Vol. 119, No. 6, 01.06.2012, p. 1227-1233.

Research output: Contribution to journalArticle

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T1 - Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women

AU - Carreno, Carlos A.

AU - Clifton, Rebecca G.

AU - Hauth, John C.

AU - Myatt, Leslie

AU - Roberts, James M.

AU - Spong, Catherine Y.

AU - Varner, Michael W.

AU - Thorp, John M.

AU - Mercer, Brian M.

AU - Peaceman, Alan M

AU - Ramin, Susan M.

AU - Carpenter, Marshall W.

AU - Sciscione, Anthony

AU - Tolosa, Jorge E.

AU - Sorokin, Yoram

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Objective: To estimate whether there is an association between excessive early gestational weight gain and the development of gestational diabetes mellitus (GDM) and excessive fetal growth. Methods: This is a secondary analysis of a randomized controlled trial of vitamins C and E in nulliparous low-risk women. Maternal weight gain from prepregnancy (self-reported) to 15-18 weeks of gestation was measured, and expected gestational weight gain was determined using the Institute of Medicine 2009 guidelines for each prepregnancy body mass index category. Excessive early gestational weight gain was defined as gestational weight gain greater than the upper range of the Institute of Medicine guidelines. Rates of GDM, birth weight greater than 4,000 g, and large for gestational age (LGA, birth weight 90 percentile or higher) were calculated and compared between women with excessive early gestational weight gain and early nonexcessive gestational weight gain (within or below Institute of Medicine guidelines). Results: A total of 7,985 women were studied. Excessive early gestational weight gain occurred in 47.5% of women. Ninety-three percent of women with excessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines. In contrast, only 55% of women with nonexcessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines (P<.001). Rates of GDM, LGA, and birth weight greater than 4,000 g were higher in women with excessive early gestational weight gain. Conclusion: In our population, excessive early gestational weight gain occurred in 93% of women who had total gestational weight gain greater than the Institute of Medicine guidelines. In low-risk nulliparous women, excessive early gestational weight gain is associated with the development of GDM and excessive fetal growth.

AB - Objective: To estimate whether there is an association between excessive early gestational weight gain and the development of gestational diabetes mellitus (GDM) and excessive fetal growth. Methods: This is a secondary analysis of a randomized controlled trial of vitamins C and E in nulliparous low-risk women. Maternal weight gain from prepregnancy (self-reported) to 15-18 weeks of gestation was measured, and expected gestational weight gain was determined using the Institute of Medicine 2009 guidelines for each prepregnancy body mass index category. Excessive early gestational weight gain was defined as gestational weight gain greater than the upper range of the Institute of Medicine guidelines. Rates of GDM, birth weight greater than 4,000 g, and large for gestational age (LGA, birth weight 90 percentile or higher) were calculated and compared between women with excessive early gestational weight gain and early nonexcessive gestational weight gain (within or below Institute of Medicine guidelines). Results: A total of 7,985 women were studied. Excessive early gestational weight gain occurred in 47.5% of women. Ninety-three percent of women with excessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines. In contrast, only 55% of women with nonexcessive early gestational weight gain had total gestational weight gain greater than Institute of Medicine guidelines (P<.001). Rates of GDM, LGA, and birth weight greater than 4,000 g were higher in women with excessive early gestational weight gain. Conclusion: In our population, excessive early gestational weight gain occurred in 93% of women who had total gestational weight gain greater than the Institute of Medicine guidelines. In low-risk nulliparous women, excessive early gestational weight gain is associated with the development of GDM and excessive fetal growth.

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