Excessive lipofuscin accumulation in the thyroid gland in mucoviscidosis

D. M. Borel, J. K. Reddy

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Thyroid glands from 19 cases of fibrocystic disease of the pancreas (mucoviscidosis) were reviewed. In 7 patients over 12 yr of age, the thyroid glands contained excessive quantities of lipofuscin pigment in the follicular epithelial cells when compared with appropriate controls. The amount of lipofuscin pigment in the thyroid glands in mucoviscidosis appears to be related to the age at the time of death, because no significant accumulation of pigment was noted in children who died within one yr of age. It is suggested that excess accumulation of lipofuscin pigment in the thyroid gland in this disease entity may be related to chronic vitamin E deficiency resulting in possible auto oxidation of lipids within the acinar cells of the thyroid gland.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume96
Issue number4
StatePublished - 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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