Excitatory components of the mammalian locomotor CPG

Ole Kiehn*, Katharina A. Quinlan, Carlos Ernesto Restrepo, Line Lundfald, Lotta Borgius, Adolfo E. Talpalar, Toshiaki Endo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Locomotion in mammals is to a large degree controlled directly by intrinsic spinal networks, called central pattern generators (CPGs). The overall function of these networks is governed by interaction between inhibitory and excitatory neurons. In the present review, we will discuss recent findings addressing the role of excitatory synaptic transmission for network function including the role of specific excitatory neuronal populations in coordinating muscle activity and in generating rhythmic activity.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalBrain Research Reviews
Volume57
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Commissural interneuron
  • Locomotion
  • Motor neuron
  • Spinal cord
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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