TY - JOUR
T1 - Excitatory components of the mammalian locomotor CPG
AU - Kiehn, Ole
AU - Quinlan, Katharina A.
AU - Restrepo, Carlos Ernesto
AU - Lundfald, Line
AU - Borgius, Lotta
AU - Talpalar, Adolfo E.
AU - Endo, Toshiaki
N1 - Funding Information:
Work in Kiehn laboratory is supported by grants from NIH, Wings of Life, Schellenberg Foundation, and from the Swedish Research Council. We thank our colleagues for fruitful discussions of issues raised in this review.
PY - 2008/1
Y1 - 2008/1
N2 - Locomotion in mammals is to a large degree controlled directly by intrinsic spinal networks, called central pattern generators (CPGs). The overall function of these networks is governed by interaction between inhibitory and excitatory neurons. In the present review, we will discuss recent findings addressing the role of excitatory synaptic transmission for network function including the role of specific excitatory neuronal populations in coordinating muscle activity and in generating rhythmic activity.
AB - Locomotion in mammals is to a large degree controlled directly by intrinsic spinal networks, called central pattern generators (CPGs). The overall function of these networks is governed by interaction between inhibitory and excitatory neurons. In the present review, we will discuss recent findings addressing the role of excitatory synaptic transmission for network function including the role of specific excitatory neuronal populations in coordinating muscle activity and in generating rhythmic activity.
KW - Commissural interneuron
KW - Locomotion
KW - Motor neuron
KW - Spinal cord
KW - Transcription factor
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U2 - 10.1016/j.brainresrev.2007.07.002
DO - 10.1016/j.brainresrev.2007.07.002
M3 - Review article
C2 - 17988744
AN - SCOPUS:36749008469
VL - 57
SP - 56
EP - 63
JO - Brain Research Reviews
JF - Brain Research Reviews
SN - 0165-0173
IS - 1
ER -