Executive functions in multiple sclerosis

An analysis of temporal ordering, semantic encoding, and planning abilities

Peter A. Arnett*, Jordan Grafman, Stephen M. Rao, Linda Bernardin, Tracey Luchetta, Jeffrey R. Binder, Lorri Lobeck

*Corresponding author for this work

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Previous studies have consistently demonstrated impairments in conceptual reasoning and set-shifting abilities in patients with multiple sclerosis (MS). Other executive functions have been less frequently examined. We compared 44 MS patients and 48 demographically matched controls on a temporal-ordering and semantic-encoding task and on a test of planning (Tower of Hanoi). Compared with controls, MS patients experienced deficient semantic encoding and planning but unimpaired temporal-order memory. For both tasks, post hoc analyses indicated that chronic-progressive MS patients contributed most to the group differences. A combination of poor planning and slowed information-processing speed was hypothesized to have contributed to MS patients' impaired Tower of Hanoi performance. Further research is needed to explore the possible relationship between semantic-encoding and planning deficits in MS and social and occupational disabilities.

Original languageEnglish (US)
Pages (from-to)535-544
Number of pages10
JournalNeuropsychology
Volume11
Issue number4
DOIs
StatePublished - Nov 5 1997

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Aptitude
Executive Function
Semantics
Multiple Sclerosis
Chronic Progressive Multiple Sclerosis
Automatic Data Processing
Research

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Arnett, Peter A. ; Grafman, Jordan ; Rao, Stephen M. ; Bernardin, Linda ; Luchetta, Tracey ; Binder, Jeffrey R. ; Lobeck, Lorri. / Executive functions in multiple sclerosis : An analysis of temporal ordering, semantic encoding, and planning abilities. In: Neuropsychology. 1997 ; Vol. 11, No. 4. pp. 535-544.
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Executive functions in multiple sclerosis : An analysis of temporal ordering, semantic encoding, and planning abilities. / Arnett, Peter A.; Grafman, Jordan; Rao, Stephen M.; Bernardin, Linda; Luchetta, Tracey; Binder, Jeffrey R.; Lobeck, Lorri.

In: Neuropsychology, Vol. 11, No. 4, 05.11.1997, p. 535-544.

Research output: Contribution to journalArticle

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