Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities

Peter A. Arnett*, Jordan Grafman, Stephen M. Rao, Linda Bernardin, Tracey Luchetta, Jeffrey R. Binder, Lorri Lobeck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Previous studies have consistently demonstrated impairments in conceptual reasoning and set-shifting abilities in patients with multiple sclerosis (MS). Other executive functions have been less frequently examined. We compared 44 MS patients and 48 demographically matched controls on a temporal-ordering and semantic-encoding task and on a test of planning (Tower of Hanoi). Compared with controls, MS patients experienced deficient semantic encoding and planning but unimpaired temporal-order memory. For both tasks, post hoc analyses indicated that chronic-progressive MS patients contributed most to the group differences. A combination of poor planning and slowed information-processing speed was hypothesized to have contributed to MS patients' impaired Tower of Hanoi performance. Further research is needed to explore the possible relationship between semantic-encoding and planning deficits in MS and social and occupational disabilities.

Original languageEnglish (US)
Pages (from-to)535-544
Number of pages10
JournalNeuropsychology
Volume11
Issue number4
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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