Exercise Stress Testing: Diagnostic Utility in the Evaluation of Long QT Syndrome

Stephanie F. Chandler, Robyn J. Hylind, Dominic J. Abrams*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Congenital long QT syndrome (LQTS), an inherited disorder of ventricular repolarization, is characterized by a prolonged QT interval and T-wave morphological changes on the surface electrocardiogram (EKG) with associated symptoms of syncope, seizures, cardiac arrest, and sudden death. Multiple studies in adults and a few in pediatric patients have demonstrated the value of performing exercise stress tests (EST) as a diagnostic tool in the evaluation of patients with suspected LQTS. As LQTS demonstrates reduced penetrance and many patients are asymptomatic, affected individuals with LQTS can be erroneously considered unaffected if only clinical features and resting EKG are utilized for diagnostic purposes. EST—and specifically—QTc interval prolongation during recovery after EST has been demonstrated to be a sensitive screening test for LQTS.

Original languageEnglish (US)
Title of host publicationExercise Physiology for the Pediatric and Congenital Cardiologist
PublisherSpringer International Publishing
Pages219-226
Number of pages8
ISBN (Electronic)9783030168186
ISBN (Print)9783030168179
DOIs
StatePublished - Jan 1 2019

Keywords

  • Exercise stress testing
  • Genetics
  • Long QT syndrome
  • Sudden death
  • Torsades de pointes

ASJC Scopus subject areas

  • General Medicine

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