Exercise's effect on mobility disability in older adults with and without obesity

The LIFE study randomized clinical trial

Stephen B. Kritchevsky*, Laura Lovato, Elizabeth P. Handing, Steven Blair, Anda Botoseneanu, Jack M. Guralnik, Christine Liu, Abby King, Anthony P. Marsh, Marco Pahor, W. Jack Rejeski, Bonnie Spring, Todd Manini

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program. Methods: MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2.6 years. Participants were divided into four subgroups: (1) nonobese (BMI < 30 kg/m 2 ; n = 437); (2) nonobese with high waist circumference (WC > 102 cm [men], > 88 cm [women]; n = 434); (3) class 1 obesity (30 kg/m 2 ≤ BMI < 35 kg/m 2 ; n = 430); and (4) class 2 + obesity (BMI ≥ 35 kg/m 2 ; n = 312). Cox proportional hazard modeling was used to test an obesity by intervention interaction. Results: The PA intervention had the largest benefit in participants with class 2 + obesity (hazard ratio 0.69, 95% confidence interval 0.48, 0.98). However, there was no statistically significant difference in benefit across obesity categories. Conclusions: A structured PA program reduced the risk of MMD even in older adults with extreme obesity.

Original languageEnglish (US)
Pages (from-to)1199-1205
Number of pages7
JournalObesity
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Life Style
Randomized Controlled Trials
Obesity
Exercise
Physical Education and Training
Waist Circumference
Health Education
Confidence Intervals

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Kritchevsky, S. B., Lovato, L., Handing, E. P., Blair, S., Botoseneanu, A., Guralnik, J. M., ... Manini, T. (2017). Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial. Obesity, 25(7), 1199-1205. https://doi.org/10.1002/oby.21860
Kritchevsky, Stephen B. ; Lovato, Laura ; Handing, Elizabeth P. ; Blair, Steven ; Botoseneanu, Anda ; Guralnik, Jack M. ; Liu, Christine ; King, Abby ; Marsh, Anthony P. ; Pahor, Marco ; Rejeski, W. Jack ; Spring, Bonnie ; Manini, Todd. / Exercise's effect on mobility disability in older adults with and without obesity : The LIFE study randomized clinical trial. In: Obesity. 2017 ; Vol. 25, No. 7. pp. 1199-1205.
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abstract = "Objective: Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program. Methods: MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2.6 years. Participants were divided into four subgroups: (1) nonobese (BMI < 30 kg/m 2 ; n = 437); (2) nonobese with high waist circumference (WC > 102 cm [men], > 88 cm [women]; n = 434); (3) class 1 obesity (30 kg/m 2 ≤ BMI < 35 kg/m 2 ; n = 430); and (4) class 2 + obesity (BMI ≥ 35 kg/m 2 ; n = 312). Cox proportional hazard modeling was used to test an obesity by intervention interaction. Results: The PA intervention had the largest benefit in participants with class 2 + obesity (hazard ratio 0.69, 95{\%} confidence interval 0.48, 0.98). However, there was no statistically significant difference in benefit across obesity categories. Conclusions: A structured PA program reduced the risk of MMD even in older adults with extreme obesity.",
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Kritchevsky, SB, Lovato, L, Handing, EP, Blair, S, Botoseneanu, A, Guralnik, JM, Liu, C, King, A, Marsh, AP, Pahor, M, Rejeski, WJ, Spring, B & Manini, T 2017, 'Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial', Obesity, vol. 25, no. 7, pp. 1199-1205. https://doi.org/10.1002/oby.21860

Exercise's effect on mobility disability in older adults with and without obesity : The LIFE study randomized clinical trial. / Kritchevsky, Stephen B.; Lovato, Laura; Handing, Elizabeth P.; Blair, Steven; Botoseneanu, Anda; Guralnik, Jack M.; Liu, Christine; King, Abby; Marsh, Anthony P.; Pahor, Marco; Rejeski, W. Jack; Spring, Bonnie; Manini, Todd.

In: Obesity, Vol. 25, No. 7, 01.07.2017, p. 1199-1205.

Research output: Contribution to journalArticle

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T1 - Exercise's effect on mobility disability in older adults with and without obesity

T2 - The LIFE study randomized clinical trial

AU - Kritchevsky, Stephen B.

AU - Lovato, Laura

AU - Handing, Elizabeth P.

AU - Blair, Steven

AU - Botoseneanu, Anda

AU - Guralnik, Jack M.

AU - Liu, Christine

AU - King, Abby

AU - Marsh, Anthony P.

AU - Pahor, Marco

AU - Rejeski, W. Jack

AU - Spring, Bonnie

AU - Manini, Todd

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective: Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program. Methods: MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2.6 years. Participants were divided into four subgroups: (1) nonobese (BMI < 30 kg/m 2 ; n = 437); (2) nonobese with high waist circumference (WC > 102 cm [men], > 88 cm [women]; n = 434); (3) class 1 obesity (30 kg/m 2 ≤ BMI < 35 kg/m 2 ; n = 430); and (4) class 2 + obesity (BMI ≥ 35 kg/m 2 ; n = 312). Cox proportional hazard modeling was used to test an obesity by intervention interaction. Results: The PA intervention had the largest benefit in participants with class 2 + obesity (hazard ratio 0.69, 95% confidence interval 0.48, 0.98). However, there was no statistically significant difference in benefit across obesity categories. Conclusions: A structured PA program reduced the risk of MMD even in older adults with extreme obesity.

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Kritchevsky SB, Lovato L, Handing EP, Blair S, Botoseneanu A, Guralnik JM et al. Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial. Obesity. 2017 Jul 1;25(7):1199-1205. https://doi.org/10.1002/oby.21860