Existing models fail to predict sepsis in an obstetric population with intrauterine infection

Justin R. Lappen*, Melissa Keene, Marybeth Lore, William A. Grobman, Dana R. Gossett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


OBJECTIVE: Multiple scoring systems exist to identify inpatients who are at risk for clinical deterioration. None of these systems have been evaluated in an obstetric population. We examined the Systemic Inflammatory Response syndrome (SIRS) and Modified Early Warning score (MEWS) criteria in pregnant women with chorioamnionitis. STUDY DESIGN: This was an 18-month retrospective analysis of patients with chorioamnionitis. SIRS and MEWS scores were calculated; clinical outcomes were ascertained, and test characteristics were calculated for the primary outcome of sepsis, intensive care unit transfer, or death. RESULTS: Nine hundred thirteen women with chorioamnionitis were identified. Five women experienced sepsis; there was 1 death. Five hundred seventy-five of the 913 women (63%) met SIRS criteria (95% confidence interval, 59.8-66.2%; positive predictive value, 0.9%). Ninety-two of the 913 women (10.3%) had a MEWS score of ≥5 (95% confidence interval, 8.3-12.2%; positive predictive value, 0.05%). CONCLUSION: SIRS and MEWS criteria do not identify accurately patients who are at risk for intensive care unit transfer, sepsis, or death among pregnant women with intrauterine infection and should not be used in an obstetric setting.

Original languageEnglish (US)
Pages (from-to)573.e1-573.e5
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Dec 2010


  • Chorioamnionitis
  • Intensive care unit
  • MEWS
  • Sepsis

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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