Exocytosed protons feedback to suppress the Ca2+ current in mammalian cone photoreceptors

Steven H. DeVries*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


A proton pump acidifies synaptic vesicles and provides the electrochemical gradient for transmitter uptake. Although external protons can modulate membrane voltage- and ligand-gated conductances, the fate of the protons released when vesicles fuse with the plasma membrane is unclear. In the dark, the glutamate-laden vesicles of cone photoreceptors fuse continuously with the plasma membrane. I now show that vesicular protons feed back to block the nearby calcium channels that mediate release. This local proton-mediated feedback is a novel mechanism through which neurons may regulate the release of transmitter.

Original languageEnglish (US)
Pages (from-to)1107-1117
Number of pages11
Issue number6
StatePublished - Dec 20 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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