Expanding roles for miRNAs and siRNAs in cell regulation

Kenji Nakahara*, Richard W Carthew

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume16
Issue number2
DOIs
StatePublished - Apr 1 2004

Keywords

  • DCL
  • Dicer-like
  • RISC
  • RNA-induced silencing complex
  • miRNA
  • miRNP
  • micro ribonucleoprotein complex
  • microRNA
  • short interfering RNA
  • siRNA

ASJC Scopus subject areas

  • Cell Biology

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