Expanding roles for miRNAs and siRNAs in cell regulation

Kenji Nakahara; Richard W. Carthew

doi:10.1016/j.ceb.2004.02.006

Expanding roles for miRNAs and siRNAs in cell regulation

Kenji Nakahara^*, Richard W. Carthew

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.ceb.2004.02.006
State	Published - Apr 2004

Keywords

DCL
Dicer-like
RISC
RNA-induced silencing complex
miRNA
miRNP
micro ribonucleoprotein complex
microRNA
short interfering RNA
siRNA

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2004.02.006

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title = "Expanding roles for miRNAs and siRNAs in cell regulation",

abstract = "The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.",

keywords = "DCL, Dicer-like, RISC, RNA-induced silencing complex, miRNA, miRNP, micro ribonucleoprotein complex, microRNA, short interfering RNA, siRNA",

author = "Kenji Nakahara and Carthew, {Richard W.}",

note = "Funding Information: The authors thank Takashi Hayashi for help with Figure 3 , and Erik Sontheimer for helpful comments. The authors are supported by a grant from the National Institutes of Health GM68743. ",

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T1 - Expanding roles for miRNAs and siRNAs in cell regulation

AU - Nakahara, Kenji

AU - Carthew, Richard W.

N1 - Funding Information: The authors thank Takashi Hayashi for help with Figure 3 , and Erik Sontheimer for helpful comments. The authors are supported by a grant from the National Institutes of Health GM68743.

PY - 2004/4

Y1 - 2004/4

N2 - The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.

AB - The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.

KW - DCL

KW - Dicer-like

KW - RISC

KW - RNA-induced silencing complex

KW - miRNA

KW - miRNP

KW - micro ribonucleoprotein complex

KW - microRNA

KW - short interfering RNA

KW - siRNA

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U2 - 10.1016/j.ceb.2004.02.006

DO - 10.1016/j.ceb.2004.02.006

M3 - Review article

C2 - 15196554

AN - SCOPUS:2942620391

SN - 0955-0674

VL - 16

SP - 127

EP - 133

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 2

ER -

Expanding roles for miRNAs and siRNAs in cell regulation

Abstract

Keywords

ASJC Scopus subject areas

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