Experience-dependent and independent binocular correspondence of receptive field subregions in mouse visual cortex

Rashmi Sarnaik*, Bor Shuen Wang, Jianhua Cang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The convergence of eye-specific thalamic inputs to visual cortical neurons forms the basis of binocular vision. Inputs from the same eye that signal light increment (On) and decrement (Off) are spatially segregated into subregions, giving rise to cortical receptive fields (RFs) that are selective for stimulus orientation. Here we map RFs of binocular neurons in the mouse primary visual cortex using spike-triggered average. We find that subregions of the same sign (On-On and Off-Off) preferentially overlap between the 2 monocular RFs, leading to binocularly matched orientation tuning. We further demonstrate that such subregion correspondence and the consequent matching of RF orientation are disrupted in mice reared in darkness during development. Surprisingly, despite the lack of all postnatal visual experience, a substantial degree of subregion correspondence still remains. In addition, dark-reared mice show normal monocular RF structures and binocular overlap. These results thus reveal the specific roles of experience-dependent and-independent processes in binocular convergence and refinement of On and Off inputs onto single cortical neurons.

Original languageEnglish (US)
Pages (from-to)1658-1670
Number of pages13
JournalCerebral Cortex
Volume24
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Binocular matching
  • Critical period
  • Development
  • Orientation selectivity
  • Spike-triggered average

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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