Experimental Cell Therapy for Liver Dysfunction

Bo Wang*, Jason A. Wertheim

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver transplantation is the established therapy for inherited hepatic disorders and end-stage liver failures; however, the serious organ shortage has restricted its wide application. Hepatocyte transplantation has shown potential as an alternative therapy for liver transplantation and has also been considered as a "bridge" therapy until a liver for transplantation becomes available. The current cell source for hepatocyte transplantation is usually isolated from donor livers that are not used for liver transplantation. This has led to the short supply of high-quality primary hepatocytes that limit the application of hepatocytes transplantation as a routine clinical practice. This chapter will review the latest scientific developments and major challenges that may one day lead to a wider application of hepatocyte transplantation.

Original languageEnglish (US)
Title of host publicationTranslating Regenerative Medicine to the Clinic
PublisherElsevier Inc
Pages309-313
Number of pages5
ISBN (Electronic)9780128005521
ISBN (Print)9780128005484
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cell tracking
  • Hepatocyte isolation
  • Hepatocyte transplantation
  • Machine perfusion
  • Magnetic resonance imaging
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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