Experimental investigations of the possible cause of liver appearance during bone scanning

A. M. Zimmer; D. G. Pavel

doi:10.1148/126.3.813

Experimental investigations of the possible cause of liver appearance during bone scanning

A. M. Zimmer, D. G. Pavel

Radiology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Rats were injected with 99mTc-Sn-diphosphonate preparations containing various concentrations of AI⁺³, ranging from 0 mug/ml to 60 mug/ml, and whole-body rat images were obtained at two hours postinjection to assess soft-tissue uptake. Uptake (kidney and liver) occurred at approximately 20 mug/ml AI⁺³. [This is the maximum allowed in pertechnetate eluate by the Nuclear Regulatory Commission (NRC)]. Increased soft-tissue uptake and progressive degradation of bone scan images occurred with higher AI⁺³ concentrations. Chromatographic analysis confirmed the breakdown of the radiopharmaceutical preparation containing 20 mug/ml or more AI⁺³. Millipore filtration showed no evidence of large colloid particles (greater than 0.2 mum).

Original language	English (US)
Pages (from-to)	813-816
Number of pages	4
Journal	Radiology
Volume	126
Issue number	3
DOIs	https://doi.org/10.1148/126.3.813
State	Published - 1978

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Experimental investigations of the possible cause of liver appearance during bone scanning",

abstract = "Rats were injected with 99mTc-Sn-diphosphonate preparations containing various concentrations of AI+3, ranging from 0 mug/ml to 60 mug/ml, and whole-body rat images were obtained at two hours postinjection to assess soft-tissue uptake. Uptake (kidney and liver) occurred at approximately 20 mug/ml AI+3. [This is the maximum allowed in pertechnetate eluate by the Nuclear Regulatory Commission (NRC)]. Increased soft-tissue uptake and progressive degradation of bone scan images occurred with higher AI+3 concentrations. Chromatographic analysis confirmed the breakdown of the radiopharmaceutical preparation containing 20 mug/ml or more AI+3. Millipore filtration showed no evidence of large colloid particles (greater than 0.2 mum).",

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AB - Rats were injected with 99mTc-Sn-diphosphonate preparations containing various concentrations of AI+3, ranging from 0 mug/ml to 60 mug/ml, and whole-body rat images were obtained at two hours postinjection to assess soft-tissue uptake. Uptake (kidney and liver) occurred at approximately 20 mug/ml AI+3. [This is the maximum allowed in pertechnetate eluate by the Nuclear Regulatory Commission (NRC)]. Increased soft-tissue uptake and progressive degradation of bone scan images occurred with higher AI+3 concentrations. Chromatographic analysis confirmed the breakdown of the radiopharmaceutical preparation containing 20 mug/ml or more AI+3. Millipore filtration showed no evidence of large colloid particles (greater than 0.2 mum).

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Experimental investigations of the possible cause of liver appearance during bone scanning

Abstract

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