Experimental investigations of the possible cause of liver appearance during bone scanning

A. M. Zimmer, D. G. Pavel

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Rats were injected with 99mTc-Sn-diphosphonate preparations containing various concentrations of AI+3, ranging from 0 mug/ml to 60 mug/ml, and whole-body rat images were obtained at two hours postinjection to assess soft-tissue uptake. Uptake (kidney and liver) occurred at approximately 20 mug/ml AI+3. [This is the maximum allowed in pertechnetate eluate by the Nuclear Regulatory Commission (NRC)]. Increased soft-tissue uptake and progressive degradation of bone scan images occurred with higher AI+3 concentrations. Chromatographic analysis confirmed the breakdown of the radiopharmaceutical preparation containing 20 mug/ml or more AI+3. Millipore filtration showed no evidence of large colloid particles (greater than 0.2 mum).

Original languageEnglish (US)
Pages (from-to)813-816
Number of pages4
JournalRadiology
Volume126
Issue number3
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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