Rats were injected with 99mTc-Sn-diphosphonate preparations containing various concentrations of AI+3, ranging from 0 mug/ml to 60 mug/ml, and whole-body rat images were obtained at two hours postinjection to assess soft-tissue uptake. Uptake (kidney and liver) occurred at approximately 20 mug/ml AI+3. [This is the maximum allowed in pertechnetate eluate by the Nuclear Regulatory Commission (NRC)]. Increased soft-tissue uptake and progressive degradation of bone scan images occurred with higher AI+3 concentrations. Chromatographic analysis confirmed the breakdown of the radiopharmaceutical preparation containing 20 mug/ml or more AI+3. Millipore filtration showed no evidence of large colloid particles (greater than 0.2 mum).
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging