Experimental models of virus‐induced demyelination of the central nervous system

Mauro C. Dal Canto; Stanley G. Rabinowitz

doi:10.1002/ana.410110202

Experimental models of virus‐induced demyelination of the central nervous system

Mauro C. Dal Canto^*, Stanley G. Rabinowitz

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

One of the arguments in favor of a viral pathogenesis for multiple sclerosis is the existence of several experimental and natural animal models of virus‐induced primary demyelination. This review deals comprehensively with such models. Well‐known examples of demyelinating viral infections in their natural host are JHM, Theiler, visna, and canine distemper encephalomyelitides. Recent reports of experimental murine infections with pathogens such as vesicular stomatitis, Chandipura, herpes simplex, Venezuelan equine encephalomyelitis, and Semliki Forest viruses are also discussed. The thrust of the review is to include viral models suspected of producing primary demyelination on an immunopathological basis.

Original language	English (US)
Pages (from-to)	109-127
Number of pages	19
Journal	Annals of neurology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1002/ana.410110202
State	Published - Feb 1982

ASJC Scopus subject areas

Neurology
Clinical Neurology

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