Experimental models of virus‐induced demyelination of the central nervous system

Mauro Carlo Dal Canto*, Stanley G. Rabinowitz

*Corresponding author for this work

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

One of the arguments in favor of a viral pathogenesis for multiple sclerosis is the existence of several experimental and natural animal models of virus‐induced primary demyelination. This review deals comprehensively with such models. Well‐known examples of demyelinating viral infections in their natural host are JHM, Theiler, visna, and canine distemper encephalomyelitides. Recent reports of experimental murine infections with pathogens such as vesicular stomatitis, Chandipura, herpes simplex, Venezuelan equine encephalomyelitis, and Semliki Forest viruses are also discussed. The thrust of the review is to include viral models suspected of producing primary demyelination on an immunopathological basis.

Original languageEnglish (US)
Pages (from-to)109-127
Number of pages19
JournalAnnals of neurology
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1982

Fingerprint

Demyelinating Diseases
Visna
Venezuelan Equine Encephalomyelitides
Theoretical Models
Central Nervous System
Distemper
Semliki forest virus
Encephalomyelitis
Vesicular Stomatitis
Herpes Simplex
Virus Diseases
Multiple Sclerosis
Animal Models
Infection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

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Experimental models of virus‐induced demyelination of the central nervous system. / Dal Canto, Mauro Carlo; Rabinowitz, Stanley G.

In: Annals of neurology, Vol. 11, No. 2, 01.01.1982, p. 109-127.

Research output: Contribution to journalArticle

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