Experimental models to study molecular mechanisms underlying intestinal inflammation

Charles O. Elson*, Y. Cong, S. Brandwein, C. T. Weaver, R. P. McCabe, M. Mähler, J. P. Sundberg, E. H. Leiter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalAnnals of the New York Academy of Sciences
StatePublished - 1998

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • History and Philosophy of Science


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