Estudios experimentales en cardiología

Translated title of the contribution: Experimental studies in cardiology

Javier Muñiz*, Darwin R. Labarthe, Rafael Juane, Alfonso Castro Beiras

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Experimental designs in clinical investigation are discussed in this article. Guideline examples have been used in the area of Cardiology using always the same one only one whenever possible. We have looked for a different perspective from what is generally used in the discussion of the general characteristics of experimental designs, and more specifically of clinical trials and we deal with the aspects of clinical trials which are usually ignored due to their marginal character. We also discuss those characteristics which differentiate clinical trials in respect to other designs and types of questions which are answered by clinical trials. And we finally discuss various aspects such as randomization and its various types (simple, block, stratified, pre-randomized) and variable types of evaluating the answers, masking and the problems in its maintenance, with certain kinds of designs, sample size, etc. There is a brief mention of two particular cases: factorial and cross over designs are both discussed, mentioning their strong and weak points. Likewise, we discuss community trials as another experimental design and examples are provided. Finally, we discuss aspects of criteria: such as, When to stop the trials? or Who are the results applicable to?, and we suggest points to take into consideration when these decisions are made.

Translated title of the contributionExperimental studies in cardiology
Original languageSpanish
Pages (from-to)268-277
Number of pages10
JournalRevista Espanola de Cardiologia
Issue number4
StatePublished - Jan 1 1997


  • Cardiology
  • Clinical trials
  • Community trials
  • Experimental designs
  • Primary prevention
  • Secondary prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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