TY - GEN
T1 - Experimentally Modifiable Parameters and Their Relation to the Tonic Vibration Reflex in Chronic Hemiparetic Stroke
AU - Beauchamp, James A.
AU - Patterson, Jacqueline R.
AU - Heckman, C. J.
AU - Dewald, Julius P.A.
N1 - Funding Information:
This research was supported by NIH grant R01HD039343 to J. P. A. Dewald.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/7
Y1 - 2019/7
N2 - The tonic vibration reflex (TVR), a reflexive muscle contraction resulting from muscle or tendon vibration, is a useful tool in assessing spinal motoneuron excitability, particularly in hyperexcitable conditions, such as in chronic hemiparetic stroke. The influence of experimental parameters, for example the type of vibratory stimulus and limb configuration, and their interactions on the TVR response in chronic stroke is unknown, yet this knowledge is crucial for designing experiments with reliable TVR responses. Therefore, we conducted a screening experiment of six potential driving factors affecting the TVR response, with a D-optimal split plot fractional design matrix consisting of thirty-two combinations for each of the four participants with chronic hemiparetic stroke. Our results suggest that pre-vibration muscle activation level, vibration frequency, and stimulus application force, are all significant contributors to the TVR response in chronic hemiparetic stroke, along with an interaction between elbow flexion angle and muscle activity level. This investigation highlights the sensitivity of the TVR response in chronic hemiparetic stroke and motivates future designed experiments in understanding this reflex as it relates to motoneuron excitability.
AB - The tonic vibration reflex (TVR), a reflexive muscle contraction resulting from muscle or tendon vibration, is a useful tool in assessing spinal motoneuron excitability, particularly in hyperexcitable conditions, such as in chronic hemiparetic stroke. The influence of experimental parameters, for example the type of vibratory stimulus and limb configuration, and their interactions on the TVR response in chronic stroke is unknown, yet this knowledge is crucial for designing experiments with reliable TVR responses. Therefore, we conducted a screening experiment of six potential driving factors affecting the TVR response, with a D-optimal split plot fractional design matrix consisting of thirty-two combinations for each of the four participants with chronic hemiparetic stroke. Our results suggest that pre-vibration muscle activation level, vibration frequency, and stimulus application force, are all significant contributors to the TVR response in chronic hemiparetic stroke, along with an interaction between elbow flexion angle and muscle activity level. This investigation highlights the sensitivity of the TVR response in chronic hemiparetic stroke and motivates future designed experiments in understanding this reflex as it relates to motoneuron excitability.
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U2 - 10.1109/EMBC.2019.8857014
DO - 10.1109/EMBC.2019.8857014
M3 - Conference contribution
C2 - 31946360
AN - SCOPUS:85077898132
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2302
EP - 2306
BT - 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Y2 - 23 July 2019 through 27 July 2019
ER -