Exploitation of Cytoskeletal Networks during Early Viral Infection

Derek Walsh, Mojgan Naghavi*

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Being dependent upon host transport systems to navigate the cytoplasm, viruses have evolved various strategies to manipulate cytoskeletal functions. Generally, viruses use the actin cytoskeleton to control entry and short-range transport at the cell periphery and exploit microtubules (MTs) for longer-range cytosolic transport, in some cases to reach the nucleus. While earlier studies established the fundamental importance of these networks to successful infection, the mechanistic details and true extent to which viruses usurp highly specialized host cytoskeletal regulators and motor adaptors is only beginning to emerge. This review outlines our current understanding of how cytoskeletal regulation contributes specifically to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent advances in this area.

Original languageEnglish (US)
Pages (from-to)39-50
Number of pages12
JournalTrends in Microbiology
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Virus Diseases
Viruses
Herpesviridae
Retroviridae
Actin Cytoskeleton
Microtubules
Cytoplasm
Infection

Keywords

  • actin
  • microtubules
  • motors
  • trafficking
  • uncoating
  • viruses

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

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title = "Exploitation of Cytoskeletal Networks during Early Viral Infection",
abstract = "Being dependent upon host transport systems to navigate the cytoplasm, viruses have evolved various strategies to manipulate cytoskeletal functions. Generally, viruses use the actin cytoskeleton to control entry and short-range transport at the cell periphery and exploit microtubules (MTs) for longer-range cytosolic transport, in some cases to reach the nucleus. While earlier studies established the fundamental importance of these networks to successful infection, the mechanistic details and true extent to which viruses usurp highly specialized host cytoskeletal regulators and motor adaptors is only beginning to emerge. This review outlines our current understanding of how cytoskeletal regulation contributes specifically to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent advances in this area.",
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Exploitation of Cytoskeletal Networks during Early Viral Infection. / Walsh, Derek; Naghavi, Mojgan.

In: Trends in Microbiology, Vol. 27, No. 1, 01.01.2019, p. 39-50.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Exploitation of Cytoskeletal Networks during Early Viral Infection

AU - Walsh, Derek

AU - Naghavi, Mojgan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Being dependent upon host transport systems to navigate the cytoplasm, viruses have evolved various strategies to manipulate cytoskeletal functions. Generally, viruses use the actin cytoskeleton to control entry and short-range transport at the cell periphery and exploit microtubules (MTs) for longer-range cytosolic transport, in some cases to reach the nucleus. While earlier studies established the fundamental importance of these networks to successful infection, the mechanistic details and true extent to which viruses usurp highly specialized host cytoskeletal regulators and motor adaptors is only beginning to emerge. This review outlines our current understanding of how cytoskeletal regulation contributes specifically to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent advances in this area.

AB - Being dependent upon host transport systems to navigate the cytoplasm, viruses have evolved various strategies to manipulate cytoskeletal functions. Generally, viruses use the actin cytoskeleton to control entry and short-range transport at the cell periphery and exploit microtubules (MTs) for longer-range cytosolic transport, in some cases to reach the nucleus. While earlier studies established the fundamental importance of these networks to successful infection, the mechanistic details and true extent to which viruses usurp highly specialized host cytoskeletal regulators and motor adaptors is only beginning to emerge. This review outlines our current understanding of how cytoskeletal regulation contributes specifically to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent advances in this area.

KW - actin

KW - microtubules

KW - motors

KW - trafficking

KW - uncoating

KW - viruses

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DO - 10.1016/j.tim.2018.06.008

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