Exploiting recognition-mediated assembly and reactivity in [2]rotaxane formation

Annick Vidonne, Tamara Kosikova, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A small molecular reaction network exploits recognition-mediated reactive processes in order to drive the assembly and formation of both a self-replicating linear template (thread) and a [2]rotaxane, in which the linear template is encircled by a diamide macrocycle. Complementary recognition sites, placed at strategic positions on the reactive building blocks, drive these assembly and replication processes. Template-instructed experiments show that the thread is capable of efficient self-replication and that no cross-catalytic relationships exist between the thread and the [2]rotaxane. The rate of [2]rotaxane formation is insensitive to the addition of a preformed template, however, [2]rotaxane formation does show enhanced diastereoselectivity, most likely originating from its recognition-mediated formation through a ternary reactive complex.

Original languageEnglish (US)
Pages (from-to)2592-2603
Number of pages12
JournalChemical Science
Issue number4
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Chemistry(all)


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