Exploiting the Curtin - Hammett Principle - Recognition-Mediated Acceleration of an Aldol Reaction

Sarah J. Howell, Peter R. Ashton, Neil Spencer, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

(Matrix Presented) Curtin-Hammett-Winstein-Holness kinetics are exploited in the acceleration of the aldol reaction between formylbenzo-15-crown-5 and acetylbenzo-15-crown-5. Potassium cations facilitate this acceleration through the fast, reversible formation of a 1:1:1 sandwich complex between the crown ethers and the metal cation.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalOrganic Letters
Volume3
Issue number3
DOIs
StatePublished - Feb 8 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Exploiting the Curtin - Hammett Principle - Recognition-Mediated Acceleration of an Aldol Reaction'. Together they form a unique fingerprint.

Cite this