TY - JOUR
T1 - Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use
AU - Bares, Cristina B.
AU - Chartier, Karen G.
AU - Karriker-Jaffe, Katherine J.
AU - Aliev, Fazil
AU - Mustanski, Brian
AU - Dick, Danielle
N1 - Funding Information:
The research reported in this publication was supported by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) of the National Institutes of Health under award numbers K01DA036681 (C.B.B.), K01AA021145 (K.G.C.), R01DA025039 (B.M.), K02AA018755 (D.D.), and R01AA023534 (Kendler with subcontract to K.J.K.-J.). The content is the sole responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NIDA and NIAAA had no role in the study design; collection, analysis or interpretation of the data; writing the manuscript; or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Previous research suggests that genetic risk factors may predispose to conduct problems and alcohol use in adolescence. Whether genetic risk factors interact with social contexts has not been well characterized among African American adolescents. Data came from a subsample of the Genes, Environment, and Neighborhood Initiative study comprising 501 African American adolescents, including 151 lifetime drinkers (56% female, mean age = 16.3, SD = 1.4). Genetic risk was assessed with polygenic risk scores for alcohol dependence. Analyses explored interactions between genetic risk and self-reported alcohol use, conduct problems, life stressors, and other covariates. The effects of two gene–environment interactions (G × E) were tested in the sample of alcohol exposed adolescents; one on conduct problems and the other on alcohol use. There were significant associations between polygenic risk for alcohol dependence and conduct problems. A significant G × E interaction showed the impact of genetic risk on conduct problems was stronger under conditions of high exposure to family and neighborhood stressors. Among this sample of African American adolescents, genetic risk for alcohol dependence was not directly associated with alcohol use but was related to more conduct problems. Further, the effect of genetic risk interacted with stressors from the family and neighborhood, so that the effect of genetic risk on conduct problems was stronger for individuals who reported greater stressors.
AB - Previous research suggests that genetic risk factors may predispose to conduct problems and alcohol use in adolescence. Whether genetic risk factors interact with social contexts has not been well characterized among African American adolescents. Data came from a subsample of the Genes, Environment, and Neighborhood Initiative study comprising 501 African American adolescents, including 151 lifetime drinkers (56% female, mean age = 16.3, SD = 1.4). Genetic risk was assessed with polygenic risk scores for alcohol dependence. Analyses explored interactions between genetic risk and self-reported alcohol use, conduct problems, life stressors, and other covariates. The effects of two gene–environment interactions (G × E) were tested in the sample of alcohol exposed adolescents; one on conduct problems and the other on alcohol use. There were significant associations between polygenic risk for alcohol dependence and conduct problems. A significant G × E interaction showed the impact of genetic risk on conduct problems was stronger under conditions of high exposure to family and neighborhood stressors. Among this sample of African American adolescents, genetic risk for alcohol dependence was not directly associated with alcohol use but was related to more conduct problems. Further, the effect of genetic risk interacted with stressors from the family and neighborhood, so that the effect of genetic risk on conduct problems was stronger for individuals who reported greater stressors.
KW - Adolescents
KW - Alcohol use
KW - Conduct problems
KW - Exposure to stressors
KW - Genetic risk
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U2 - 10.1007/s10964-019-01098-9
DO - 10.1007/s10964-019-01098-9
M3 - Article
C2 - 31407187
AN - SCOPUS:85070855936
SN - 0047-2891
VL - 49
SP - 1365
EP - 1378
JO - Journal of Youth and Adolescence
JF - Journal of Youth and Adolescence
IS - 7
ER -
