Abstract
A significant portion of the human proteome comprises RNA-binding proteins (RBPs) that play fundamental roles in numerous biological processes. In the last decade, there has been a staggering increase in RBP identification and classification, which has fueled interest in the evolving roles of RBPs and RBP-driven molecular mechanisms. Here, we focus on recent insights into RBP-dependent regulation of the epigenetic and transcriptional landscape. We describe advances in methodologies that define the RNA-protein interactome and machine-learning algorithms that are streamlining RBP discovery and predicting new RNA-binding regions. Finally, we present how RBP dysregulation leads to alterations in tumor-promoting gene expression and discuss the potential for targeting these RBPs for the development of new cancer therapeutics.
Original language | English (US) |
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Article number | 102136 |
Journal | Current Opinion in Genetics and Development |
Volume | 84 |
DOIs | |
State | Published - Feb 2024 |
Funding
Research in the Lauberth lab is supported by a Grant from the NIH/National Institute of General Medical Sciences ( R35 GM128900 ), the Robert H. Lurie Comprehensive Cancer Center , and Harold E Eisenberg Foundation .
ASJC Scopus subject areas
- Genetics
- Developmental Biology