Exploring new roles for RNA-binding proteins in epigenetic and gene regulation

Pedro Avila-Lopez, Shannon M. Lauberth

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

A significant portion of the human proteome comprises RNA-binding proteins (RBPs) that play fundamental roles in numerous biological processes. In the last decade, there has been a staggering increase in RBP identification and classification, which has fueled interest in the evolving roles of RBPs and RBP-driven molecular mechanisms. Here, we focus on recent insights into RBP-dependent regulation of the epigenetic and transcriptional landscape. We describe advances in methodologies that define the RNA-protein interactome and machine-learning algorithms that are streamlining RBP discovery and predicting new RNA-binding regions. Finally, we present how RBP dysregulation leads to alterations in tumor-promoting gene expression and discuss the potential for targeting these RBPs for the development of new cancer therapeutics.

Original languageEnglish (US)
Article number102136
JournalCurrent Opinion in Genetics and Development
Volume84
DOIs
StatePublished - Feb 2024

Funding

Research in the Lauberth lab is supported by a Grant from the NIH/National Institute of General Medical Sciences ( R35 GM128900 ), the Robert H. Lurie Comprehensive Cancer Center , and Harold E Eisenberg Foundation .

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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