Exploring the relationship between physiological measures of cochlear and brainstem function

S. Dhar; R. Abel; J. Hornickel; T. Nicol; E. Skoe; W. Zhao; N. Kraus

doi:10.1016/j.clinph.2009.02.172

Exploring the relationship between physiological measures of cochlear and brainstem function

S. Dhar^*, R. Abel, J. Hornickel, T. Nicol, E. Skoe, W. Zhao, N. Kraus

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Objective: Otoacoustic emissions and the speech-evoked auditory brainstem response are objective indices of peripheral auditory physiology that are used clinically for assessing hearing function. While each measure has been extensively explored, their interdependence and the relationships between them remain relatively unexplored. Methods: Distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs) were recorded from 28 normal-hearing adults. Through correlational analyses, DPOAE characteristics were compared to measures of sABR timing and frequency encoding. Data were organized into two DPOAE (Strength and Structure) and five brainstem (Onset, Spectrotemporal, Harmonics, Envelope Boundary, and Pitch) composite measures. Results: DPOAE Strength shows significant relationships with sABR Spectrotemporal and Harmonics measures. DPOAE Structure shows significant relationships with sABR Envelope Boundary. Neither DPOAE Strength nor Structure is related to sABR Pitch. Conclusions: The results of the present study show that certain aspects of the speech-evoked auditory brainstem responses are related to, or covary with, cochlear function as measured by distortion product otoacoustic emissions. Significance: These results form a foundation for future work in clinical populations. Analyzing cochlear and brainstem function in parallel in different clinical populations will provide a more sensitive clinical battery for identifying the locus of different disorders (e.g., language based learning impairments, hearing impairment).

Original language	English (US)
Pages (from-to)	959-966
Number of pages	8
Journal	Clinical Neurophysiology
Volume	120
Issue number	5
DOIs	https://doi.org/10.1016/j.clinph.2009.02.172
State	Published - May 2009

Funding

Work reported here was supported by Grants DC008420 and DC01510 from the NIH/NIDCD. We wish to thank the members of the Auditory Research Lab and the Auditory Neuroscience Lab, specifically Judy H. Song for her help with data collection and other aspects of this work. We also thank Professor Steven Zecker for his advice on appropriate statistical treatment of these data.

Keywords

Cochlea
Otoacoustic emissions
Speech encoding
Speech-evoked auditory brainstem response

ASJC Scopus subject areas

Clinical Neurology
Neurology
Sensory Systems
Physiology (medical)

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10.1016/j.clinph.2009.02.172

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title = "Exploring the relationship between physiological measures of cochlear and brainstem function",

abstract = "Objective: Otoacoustic emissions and the speech-evoked auditory brainstem response are objective indices of peripheral auditory physiology that are used clinically for assessing hearing function. While each measure has been extensively explored, their interdependence and the relationships between them remain relatively unexplored. Methods: Distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs) were recorded from 28 normal-hearing adults. Through correlational analyses, DPOAE characteristics were compared to measures of sABR timing and frequency encoding. Data were organized into two DPOAE (Strength and Structure) and five brainstem (Onset, Spectrotemporal, Harmonics, Envelope Boundary, and Pitch) composite measures. Results: DPOAE Strength shows significant relationships with sABR Spectrotemporal and Harmonics measures. DPOAE Structure shows significant relationships with sABR Envelope Boundary. Neither DPOAE Strength nor Structure is related to sABR Pitch. Conclusions: The results of the present study show that certain aspects of the speech-evoked auditory brainstem responses are related to, or covary with, cochlear function as measured by distortion product otoacoustic emissions. Significance: These results form a foundation for future work in clinical populations. Analyzing cochlear and brainstem function in parallel in different clinical populations will provide a more sensitive clinical battery for identifying the locus of different disorders (e.g., language based learning impairments, hearing impairment).",

keywords = "Cochlea, Otoacoustic emissions, Speech encoding, Speech-evoked auditory brainstem response",

author = "S. Dhar and R. Abel and J. Hornickel and T. Nicol and E. Skoe and W. Zhao and N. Kraus",

note = "Funding Information: Work reported here was supported by Grants DC008420 and DC01510 from the NIH/NIDCD. We wish to thank the members of the Auditory Research Lab and the Auditory Neuroscience Lab, specifically Judy H. Song for her help with data collection and other aspects of this work. We also thank Professor Steven Zecker for his advice on appropriate statistical treatment of these data.",

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doi = "10.1016/j.clinph.2009.02.172",

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AU - Dhar, S.

AU - Abel, R.

AU - Hornickel, J.

AU - Nicol, T.

AU - Skoe, E.

AU - Zhao, W.

AU - Kraus, N.

N1 - Funding Information: Work reported here was supported by Grants DC008420 and DC01510 from the NIH/NIDCD. We wish to thank the members of the Auditory Research Lab and the Auditory Neuroscience Lab, specifically Judy H. Song for her help with data collection and other aspects of this work. We also thank Professor Steven Zecker for his advice on appropriate statistical treatment of these data.

PY - 2009/5

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N2 - Objective: Otoacoustic emissions and the speech-evoked auditory brainstem response are objective indices of peripheral auditory physiology that are used clinically for assessing hearing function. While each measure has been extensively explored, their interdependence and the relationships between them remain relatively unexplored. Methods: Distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs) were recorded from 28 normal-hearing adults. Through correlational analyses, DPOAE characteristics were compared to measures of sABR timing and frequency encoding. Data were organized into two DPOAE (Strength and Structure) and five brainstem (Onset, Spectrotemporal, Harmonics, Envelope Boundary, and Pitch) composite measures. Results: DPOAE Strength shows significant relationships with sABR Spectrotemporal and Harmonics measures. DPOAE Structure shows significant relationships with sABR Envelope Boundary. Neither DPOAE Strength nor Structure is related to sABR Pitch. Conclusions: The results of the present study show that certain aspects of the speech-evoked auditory brainstem responses are related to, or covary with, cochlear function as measured by distortion product otoacoustic emissions. Significance: These results form a foundation for future work in clinical populations. Analyzing cochlear and brainstem function in parallel in different clinical populations will provide a more sensitive clinical battery for identifying the locus of different disorders (e.g., language based learning impairments, hearing impairment).

AB - Objective: Otoacoustic emissions and the speech-evoked auditory brainstem response are objective indices of peripheral auditory physiology that are used clinically for assessing hearing function. While each measure has been extensively explored, their interdependence and the relationships between them remain relatively unexplored. Methods: Distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs) were recorded from 28 normal-hearing adults. Through correlational analyses, DPOAE characteristics were compared to measures of sABR timing and frequency encoding. Data were organized into two DPOAE (Strength and Structure) and five brainstem (Onset, Spectrotemporal, Harmonics, Envelope Boundary, and Pitch) composite measures. Results: DPOAE Strength shows significant relationships with sABR Spectrotemporal and Harmonics measures. DPOAE Structure shows significant relationships with sABR Envelope Boundary. Neither DPOAE Strength nor Structure is related to sABR Pitch. Conclusions: The results of the present study show that certain aspects of the speech-evoked auditory brainstem responses are related to, or covary with, cochlear function as measured by distortion product otoacoustic emissions. Significance: These results form a foundation for future work in clinical populations. Analyzing cochlear and brainstem function in parallel in different clinical populations will provide a more sensitive clinical battery for identifying the locus of different disorders (e.g., language based learning impairments, hearing impairment).

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KW - Otoacoustic emissions

KW - Speech encoding

KW - Speech-evoked auditory brainstem response

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Exploring the relationship between physiological measures of cochlear and brainstem function

Abstract

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Keywords

ASJC Scopus subject areas

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