Exploring the Role of Mast Cells in Eosinophilic Esophagitis

Barry K. Wershil*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The mast cell plays a critical role in allergic responses in the gastrointestinal tract and other sites. Emerging evidence indicates that mast cells also participate in the pathogenesis of eosinophilic esophagitis, although their precise role has not been defined. This article reviews the biology of mast cells and examines the potential involvement of the cell as an effector of the inflammatory response and tissue remodeling, and as a cell that has the potential to function as an immunomodulator and limit inflammation.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalImmunology and Allergy Clinics of North America
Volume29
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Eosinophils
  • Esophagitis
  • Mast cells
  • Mediators

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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