Exposure to TMXDIR (Meta) aliphatic isocyanate and TMIR (meta) unsaturated aliphatic isocyanate: Clinical and immunologic evaluation of 96 workers

Leslie C. Grammer*, Martha A. Shaughnessy, Richard A. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We evaluated 96 workers employed at facilities that manufacture or use TMXDIR (meta) aliphatic isocyanate and TMIR (meta) unsaturated aliphatic isocyanate. We used immunoglobulin (Ig) and IgG serum antibody enzyme-linked immunosorbent assay (ELISA) studies and a questionnaire designed to identify symptoms compatible with work-related syndromes such as asthma and hypersensitivity pneumonitis. There were no workers with im-munologically induced disease due to TMIR isocyanate or TMXDIR isocyanate nor were there any workers whose questionnaires suggested new onset of asthma. Approximately 40% of workers experienced some irritant symptoms, mostly upper respiratory or ocular. One worker had low level IgE antibody against TMXDI-HSA but had no work-related respiratory symptoms. Very low-level IgG against TMI-HSA or TMXDI-HSA was present in 7% of workers, all of whom were in the high-exposure category.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalJournal of Occupational Medicine
Volume35
Issue number3
StatePublished - Mar 1993

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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