We evaluated 96 workers employed at facilities that manufacture or use TMXDIR (meta) aliphatic isocyanate and TMIR (meta) unsaturated aliphatic isocyanate. We used immunoglobulin (Ig) and IgG serum antibody enzyme-linked immunosorbent assay (ELISA) studies and a questionnaire designed to identify symptoms compatible with work-related syndromes such as asthma and hypersensitivity pneumonitis. There were no workers with im-munologically induced disease due to TMIR isocyanate or TMXDIR isocyanate nor were there any workers whose questionnaires suggested new onset of asthma. Approximately 40% of workers experienced some irritant symptoms, mostly upper respiratory or ocular. One worker had low level IgE antibody against TMXDI-HSA but had no work-related respiratory symptoms. Very low-level IgG against TMI-HSA or TMXDI-HSA was present in 7% of workers, all of whom were in the high-exposure category.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Occupational Medicine|
|State||Published - Mar 1993|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health