Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer

Li qun Zhou; Xue zhen Yang; L. Zeng; Li li Liang; Xin yu Yang; Liang Ren; Lee Chung; Zhi wen Zhang; Yan qun Na; Fang liu Gu; Ying lu Guo

Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer

Li qun Zhou^*, Xue zhen Yang, L. Zeng, Li li Liang, Xin yu Yang, Liang Ren, Lee Chung, Zhi wen Zhang, Yan qun Na, Fang liu Gu, Ying lu Guo

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.

Original language	English (US)
Pages (from-to)	93-95
Number of pages	3
Journal	Zhonghua wai ke za zhi [Chinese journal of surgery]
Volume	41
Issue number	2
State	Published - Feb 2003

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Medicine(all)

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title = "Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer",

abstract = "OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.",

author = "Zhou, {Li qun} and Yang, {Xue zhen} and L. Zeng and Liang, {Li li} and Yang, {Xin yu} and Liang Ren and Lee Chung and Zhang, {Zhi wen} and Na, {Yan qun} and Gu, {Fang liu} and Guo, {Ying lu}",

year = "2003",

month = feb,

language = "English (US)",

volume = "41",

pages = "93--95",

journal = "Zhonghua wai ke za zhi [Chinese journal of surgery]",

issn = "0529-5815",

publisher = "Zhonghua Yixuehui Zazhishe",

number = "2",

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TY - JOUR

T1 - Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer

AU - Zhou, Li qun

AU - Yang, Xue zhen

AU - Zeng, L.

AU - Liang, Li li

AU - Yang, Xin yu

AU - Ren, Liang

AU - Chung, Lee

AU - Zhang, Zhi wen

AU - Na, Yan qun

AU - Gu, Fang liu

AU - Guo, Ying lu

PY - 2003/2

Y1 - 2003/2

N2 - OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.

AB - OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.

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C2 - 12783666

AN - SCOPUS:33745581081

SN - 0529-5815

VL - 41

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JO - Zhonghua wai ke za zhi [Chinese journal of surgery]

JF - Zhonghua wai ke za zhi [Chinese journal of surgery]

IS - 2

ER -

Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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