Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer

Li qun Zhou*, Xue zhen Yang, L. Zeng, Li li Liang, Xin yu Yang, Liang Ren, Lee Chung, Zhi wen Zhang, Yan qun Na, Fang liu Gu, Ying lu Guo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalZhonghua wai ke za zhi [Chinese journal of surgery]
Volume41
Issue number2
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Medicine(all)

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