Expression and transcriptional control of human KCNE genes

Andrew L. Lundquist, Candice L. Turner, Leomar Y. Ballester, Alfred L. George*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Potassium channels are essential for a variety of cellular processes ranging from membrane excitability to cellular proliferation. The KCNE genes (KCNE1-5) encode a family of single-transmembrane-domain proteins that modulate the properties of several potassium channels, suggesting a physiologic role for these accessory subunits in many human tissues. To investigate the expression and transcriptional control of KCNE genes we mapped transcription start sites, delineated 5′ genomic structure, and characterized functional promoter elements for each gene. We identified alternatively spliced transcripts for both KCNE1 and KCNE3, including a cardiac-specific KCNE1 transcript. Analysis of relative expression levels of KCNE1-5 in a panel of human tissues revealed distinct, but overlapping, expression patterns. The coexpression of multiple functionally distinct KCNE genes in some tissues infers complex accessory subunit modification of potassium channels. Identification of the core promoter elements necessary for transcriptional control of the KCNE genes facilitates future work investigating factors responsible for tissue-specific expression as well as the discovery of promoter variants associated with disease.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalGenomics
Volume87
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • KCNE1
  • KCNE2
  • KCNE3
  • KCNE4
  • KCNE5
  • KCNQ1
  • Potassium channel
  • Promoter

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Expression and transcriptional control of human KCNE genes'. Together they form a unique fingerprint.

Cite this