TY - JOUR
T1 - Expression genetics
T2 - A different approach to cancer diagnosis and prognosis
AU - Zhang, Ming
AU - Martin, Katherine J.
AU - Sheng, Shijie
AU - Sager, Ruth
PY - 1998/2/1
Y1 - 1998/2/1
N2 - Expression genetics is a new approach to the identification of cancer-related genes. Instead of studying gene mutations at the genome level, it focuses on the investigation of heredity at the RNA level. By isolating genes whose expression is up or down regulated in cancers, expression geneticists study their function in the context of gene regulation. A major goal of expression genetics in cancer is to correct gene expression in tumors by the application of potential therapeutic agents.
AB - Expression genetics is a new approach to the identification of cancer-related genes. Instead of studying gene mutations at the genome level, it focuses on the investigation of heredity at the RNA level. By isolating genes whose expression is up or down regulated in cancers, expression geneticists study their function in the context of gene regulation. A major goal of expression genetics in cancer is to correct gene expression in tumors by the application of potential therapeutic agents.
UR - http://www.scopus.com/inward/record.url?scp=0032007550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032007550&partnerID=8YFLogxK
U2 - 10.1016/S0167-7799(97)01157-8
DO - 10.1016/S0167-7799(97)01157-8
M3 - Review article
C2 - 9487733
AN - SCOPUS:0032007550
SN - 0167-7799
VL - 16
SP - 66
EP - 71
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 2
ER -
