Expression of γ-Aminobutyric AcidA Receptor Subunits in the Vestibular System

Ali Rezaee, Alan M. Robinson, Dimitri Z. Pitovski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objectives:Profile the expression of genes encoding GABAA receptor subunits in the vestibular end organs of a rat.Materials and Methods:Using a combination of reverse transcription followed by polymerase chain reaction (PCR) with gene-specific primers, expression of mRNAs encoding 13 individual GABAA receptor subunits was examined.Results:PCR amplification products representing subunit gene expression for α1-6, β1-3, and γ1-3, but not for δ, subunits were amplified, suggesting multiple molecular levels of regulation of vestibular GABAA receptor expression. Nucleotide sequencing confirmed the identity of rat vestibular end-organs subunit cDNAs.Conclusion:These results give the most direct evidence to date that GABAA receptors composed of the detected subunits are expressed in the mammalian vestibular system, giving new support to previous investigations implicating GABA as a vestibular neurotransmitter.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalLaryngoscope
Volume109
Issue number2
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Otorhinolaryngology

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