Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma

Y. F.Chris Lau*, P. M. Chou, J. C. Iezzoni, J. A. Alonzo, L. G. Kömüves

*Corresponding author for this work

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

The gonadoblastoma locus on the Y chromosome (GBY) predisposes the dysgenetic gonads of XY females to develop in situ tumors. It has been mapped to a critical interval on the short arm and adjacent centromeric region on the Y chromosome. Currently there are five functional genes identified on the GBY critical region, thereby providing likely candidates for this cancer predisposition locus. To evaluate the candidacy of one of these five genes, testis-specific protein Y-encoded (TSPY), as the gene for GBY, expression patterns of TSPY in four gonadoblastoma from three patients were analyzed by immunohistochemistry using a TSPY specific antibody. Results from this study showed that TSPY was preferentially expressed in tumor germ cells of all gonadoblastoma specimens. Additional study on two cases of testicular seminoma demonstrated that TSPY was also abundantly expressed in all stages of these germ cell tumors. The present observations suggest that TSPY may either be involved in the oncogenesis of or be a useful marker for both types of germ cell tumors.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalCytogenetics and Cell Genetics
Volume91
Issue number1-4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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