Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Daniel P. Donato, Matthew T. Johnson, Ximing J. Yang, Debra L. Zynger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Aims: High expression of carbonic anhydrase IX (CAIX) is reported for clear cell renal cell carcinoma (RCC), with a paucity of data for non-renal genitourinary or adrenal tumours. This study investigated the immunohistochemical expression of CAIX throughout the genitourinary tract and adrenal gland. Methods and results: High expression in the renal cortex was restricted to clear cell, papillary and clear cell papillary RCC and carcinoid. Core biopsies of clear cell RCC were consistently positive. Positivity within the urothelial tract was seen in urothelial carcinoma including squamous, small-cell, sarcomatoid and adenomatous differentiation and clear cell adenocarcinoma. Signet ring and plasmacytoid variants of urothelial carcinoma were negative. Phaeochromocytoma, adrenal cortical adenoma, seminoma, yolk sac tumour, choriocarcinoma, Leydig cell tumour and prostatic adenocarcinoma were predominately negative, with variable reactivity in adrenal cortical carcinoma, embryonal carcinoma, teratoma and Sertoli cell tumour. Conclusions: Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available.

Original languageEnglish (US)
Pages (from-to)1229-1239
Number of pages11
Issue number6
StatePublished - Dec 2011


  • Adrenal
  • Carbonic anhydrase IX
  • Immunohistochemistry
  • Testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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