Expression of functional chemokine receptors by rat cerebellar neurons

Samantha E. Gillard, Meiling Lu, Rose M. Mastracci, Richard J. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


In this study, we examined chemokine receptor expression and function in rat cerebellar neurons. Calcium imaging experiments demonstrated that a wide variety of chemokines elicited [Ca2+]i transients in acutely isolated and cultured cerebellar Purkinje and granule neurons. In many cases, these chemokine responses were pertussis toxin (PTX) insensitive. In addition, chemokines activated the Ca2+ and cAMP-dependent transcription factor CREB and the extracellular response kinases ERK1/ERK2. Chemokines increased the survival of Purkinje neurons deprived of their trophic support. Thus, the presence of chemokine receptors and the signaling pathways they activate suggest that chemokines play a role in the control of cerebellar neuron survival and development and may mediate communication between the CNS and the immune system.

Original languageEnglish (US)
Pages (from-to)16-28
Number of pages13
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - 2002


  • Calcium mobilization
  • Cerebellar neurons
  • Chemokines
  • Signal transduction
  • Viralkines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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